Serum antibody response to Chlamydia trachomatis TroA and HtrA in women with tubal factor infertility

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Rantsi , T , Joki-Korpela , P , Hokynar , K , Kalliala , I , Öhman , H , Surcel , H-M , Paavonen , J , Tiitinen , A & Puolakkainen , M 2018 , ' Serum antibody response to Chlamydia trachomatis TroA and HtrA in women with tubal factor infertility ' , European Journal of Clinical Microbiology & Infectious Diseases , vol. 37 , no. 8 , pp. 1499-1502 . https://doi.org/10.1007/s10096-018-3276-9

Title: Serum antibody response to Chlamydia trachomatis TroA and HtrA in women with tubal factor infertility
Author: Rantsi, T.; Joki-Korpela, P.; Hokynar, K.; Kalliala, I.; Öhman, H.; Surcel, H-M.; Paavonen, J.; Tiitinen, A.; Puolakkainen, M.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Medicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Medicum
Date: 2018-08
Language: eng
Number of pages: 4
Belongs to series: European Journal of Clinical Microbiology & Infectious Diseases
ISSN: 0934-9723
URI: http://hdl.handle.net/10138/303671
Abstract: Persistent genital chlamydial infection may lead to tubal factor infertility (TFI). Chlamydia trachomatis TroA and HtrA are proteins expressed during persistent chlamydial infection in vitro. We studied serum IgG antibody response against these proteins by EIA in women with TFI and in subfertile women without tubal pathology. Altogether, 22 of 258 subfertile women (8.5%) had TFI which was unilateral in 17 cases and bilateral in 5 cases. Overall, 55 (21.3%) of the 258 women had TroA and 39 (15.1%) had HtrA antibodies. Seropositivity to TroA and HtrA was more common among women with TFI than women with other causes for subfertility (45.5 vs. 19.1%, p = 0.004 for TroA; 36.4 vs. 13.1%, p = 0.004 for HtrA). Mean absorbance values and the prevalence of TroA and HtrA antibodies increased with increasing severity of TFI. On the basis of our results, TroA and HtrA serology has the potential to be further developed to a specific biomarker for C. trachomatis-related TFI.
Subject: Chlamydia trachomatis
Persistent infection
TroA
HtrA
Serology
Tubal factor infertility
INFECTION
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
1183 Plant biology, microbiology, virology
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