Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma

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Kylmä , A K , Jouhi , L , Listyarifah , D , Mohamed , H , Mäkitie , A , Remes , S M , Haglund , C , Atula , T , Nieminen , M T , Sorsa , T & Hagström , J 2018 , ' Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma ' , British Journal of Cancer , vol. 119 , no. 1 , pp. 89-95 . https://doi.org/10.1038/s41416-018-0143-5

Title: Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma
Author: Kylmä, Anna Kaisa; Jouhi, Lauri; Listyarifah, Dyah; Mohamed, Hesham; Mäkitie, Antti; Remes, Satu Maria; Haglund, Caj; Atula, Timo; Nieminen, Mikko T.; Sorsa, Timo; Hagström, Jaana
Contributor: University of Helsinki, HUSLAB
University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
University of Helsinki, Clinicum
University of Helsinki, Department of Pathology
University of Helsinki, Clinicum
University of Helsinki, HUSLAB
University of Helsinki, Translational Cancer Biology (TCB) Research Programme
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Medicum
Date: 2018-07-03
Language: eng
Number of pages: 7
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
URI: http://hdl.handle.net/10138/303672
Abstract: BACKGROUND: An opportunistic oral pathogen, Treponema denticola (Td), has been linked to orodigestive carcinogenesis, but its role in oropharyngeal squamous cell carcinoma (OPSCC) has remained open. We evaluated the presence of Td chymotrypsin-like protease (Td-CTLP) in a series of 201 unselected consecutive OPSCC patients, and the relation of the Td-CTLP to human papillomavirus (HPV) status, to expression of toll-like receptors (TLR) 5, 7, and 9, and to clinical parameters and patient outcome. METHODS: Clinicopathological data came from hospital registries. The expression of cell surface-bound Td-CTLP was evaluated by immunohistochemistry. Immunoexpression of TLRs 5, 7, and 9, and HPV status we studied earlier in this patient series. RESULTS: We detected Td-CTLP in 81% of the OPSCC, and especially in HPV-negative tumours (48% of all OPSCCs). Among the HPV-positive tumours (52% of all OPSCCs), low Td-CTLP expression associated with low TLR 5 and high TLR 7 expression. Among those HPV-negative, higher TLR 5 and lower TLR 7 expression associated with high Td-CTLP expression. Strong Td-CTLP expression associated with poor disease-specific survival, but no similar association among HPV-positive and HPV-negative subgroups emerged. CONCLUSIONS: Td-CTLP was highly expressed in OPSCC and was associated with the HPV status of tumour tissue.
Subject: ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE
HUMAN-PAPILLOMAVIRUS
PORPHYROMONAS-GINGIVALIS
CHRONIC PERIODONTITIS
EPITHELIAL-CELLS
NECK CANCERS
HEAD
ATTACHMENT
CARCINOGENESIS
EPIDEMIC
3122 Cancers
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