Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma

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Kylmä , A K , Jouhi , L , Listyarifah , D , Mohamed , H , Mäkitie , A , Remes , S M , Haglund , C , Atula , T , Nieminen , M T , Sorsa , T & Hagström , J 2018 , ' Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma ' , British Journal of Cancer , vol. 119 , no. 1 , pp. 89-95 . https://doi.org/10.1038/s41416-018-0143-5

Title: Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma
Author: Kylmä, Anna Kaisa; Jouhi, Lauri; Listyarifah, Dyah; Mohamed, Hesham; Mäkitie, Antti; Remes, Satu Maria; Haglund, Caj; Atula, Timo; Nieminen, Mikko T.; Sorsa, Timo; Hagström, Jaana
Contributor organization: HUSLAB
Korva-, nenä- ja kurkkutautien klinikka
Department of Ophthalmology and Otorhinolaryngology
Clinicum
University of Helsinki
Department of Oral and Maxillofacial Diseases
Department of Pathology
Medicum
Translational Cancer Biology (TCB) Research Programme
Department of Surgery
II kirurgian klinikka
Research Programs Unit
Doctoral Programme in Integrative Life Science
Timo Sorsa / Principal Investigator
Suu- ja leukakirurgian yksikkö
HUS Head and Neck Center
HUS Abdominal Center
Date: 2018-07-03
Language: eng
Number of pages: 7
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
DOI: https://doi.org/10.1038/s41416-018-0143-5
URI: http://hdl.handle.net/10138/303672
Abstract: BACKGROUND: An opportunistic oral pathogen, Treponema denticola (Td), has been linked to orodigestive carcinogenesis, but its role in oropharyngeal squamous cell carcinoma (OPSCC) has remained open. We evaluated the presence of Td chymotrypsin-like protease (Td-CTLP) in a series of 201 unselected consecutive OPSCC patients, and the relation of the Td-CTLP to human papillomavirus (HPV) status, to expression of toll-like receptors (TLR) 5, 7, and 9, and to clinical parameters and patient outcome. METHODS: Clinicopathological data came from hospital registries. The expression of cell surface-bound Td-CTLP was evaluated by immunohistochemistry. Immunoexpression of TLRs 5, 7, and 9, and HPV status we studied earlier in this patient series. RESULTS: We detected Td-CTLP in 81% of the OPSCC, and especially in HPV-negative tumours (48% of all OPSCCs). Among the HPV-positive tumours (52% of all OPSCCs), low Td-CTLP expression associated with low TLR 5 and high TLR 7 expression. Among those HPV-negative, higher TLR 5 and lower TLR 7 expression associated with high Td-CTLP expression. Strong Td-CTLP expression associated with poor disease-specific survival, but no similar association among HPV-positive and HPV-negative subgroups emerged. CONCLUSIONS: Td-CTLP was highly expressed in OPSCC and was associated with the HPV status of tumour tissue.
Subject: ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE
HUMAN-PAPILLOMAVIRUS
PORPHYROMONAS-GINGIVALIS
CHRONIC PERIODONTITIS
EPITHELIAL-CELLS
NECK CANCERS
HEAD
ATTACHMENT
CARCINOGENESIS
EPIDEMIC
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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