Vaginal Microbiota Composition Correlates Between Pap Smear Microscopy and Next Generation Sequencing and Associates to Socioeconomic Status

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Virtanen , S , Rantsi , T , Virtanen , A , Kervinen , K , Nieminen , P , Kalliala , I & Salonen , A 2019 , ' Vaginal Microbiota Composition Correlates Between Pap Smear Microscopy and Next Generation Sequencing and Associates to Socioeconomic Status ' , Scientific Reports , vol. 9 , 7750 . https://doi.org/10.1038/s41598-019-44157-8

Title: Vaginal Microbiota Composition Correlates Between Pap Smear Microscopy and Next Generation Sequencing and Associates to Socioeconomic Status
Author: Virtanen, Seppo; Rantsi, Tiina; Virtanen, Anni; Kervinen, Kaisa; Nieminen, Pekka; Kalliala, Ilkka; Salonen, Anne
Contributor organization: Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Clinicum
Precision Cancer Pathology
HUSLAB
Department of Pathology
Medicum
Faculty of Medicine
HUMI - Human Microbiome Research
University Management
de Vos & Salonen group
University of Helsinki
Date: 2019-05-23
Language: eng
Number of pages: 9
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-019-44157-8
URI: http://hdl.handle.net/10138/303711
Abstract: Recent research on vaginal microbiota relies on high throughput sequencing while microscopic methods have a long history in clinical use. We investigated the correspondence between microscopic findings of Pap smears and the vaginal microbiota composition determined by next generation sequencing among 50 asymptomatic women. Both methods produced coherent results regarding the distinction between Lactobacillus-dominant versus mixed microbiota, reassuring gynaecologists for the use of Pap smear or wet mount microscopy for rapid evaluation of vaginal bacteria as part of diagnosis. Cytologic findings identified women with bacterial vaginosis and revealed that cytolysis of vaginal epithelial cells is associated to Lactobacillus crispatus-dominated microbiota. Education and socio-economic status were associated to the vaginal microbiota variation. Our results highlight the importance of including socio-economic status as a co-factor in future vaginal microbiota studies.
Subject: BACTERIAL VAGINOSIS
AEROBIC VAGINITIS
RISK-FACTORS
WOMEN
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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