Vaginal Microbiota Composition Correlates Between Pap Smear Microscopy and Next Generation Sequencing and Associates to Socioeconomic Status

Show full item record



Permalink

http://hdl.handle.net/10138/303711

Citation

Virtanen , S , Rantsi , T , Virtanen , A , Kervinen , K , Nieminen , P , Kalliala , I & Salonen , A 2019 , ' Vaginal Microbiota Composition Correlates Between Pap Smear Microscopy and Next Generation Sequencing and Associates to Socioeconomic Status ' , Scientific Reports , vol. 9 , 7750 . https://doi.org/10.1038/s41598-019-44157-8

Title: Vaginal Microbiota Composition Correlates Between Pap Smear Microscopy and Next Generation Sequencing and Associates to Socioeconomic Status
Author: Virtanen, Seppo; Rantsi, Tiina; Virtanen, Anni; Kervinen, Kaisa; Nieminen, Pekka; Kalliala, Ilkka; Salonen, Anne
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Precision Cancer Pathology
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUMI - Human Microbiome Research
Date: 2019-05-23
Language: eng
Number of pages: 9
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/303711
Abstract: Recent research on vaginal microbiota relies on high throughput sequencing while microscopic methods have a long history in clinical use. We investigated the correspondence between microscopic findings of Pap smears and the vaginal microbiota composition determined by next generation sequencing among 50 asymptomatic women. Both methods produced coherent results regarding the distinction between Lactobacillus-dominant versus mixed microbiota, reassuring gynaecologists for the use of Pap smear or wet mount microscopy for rapid evaluation of vaginal bacteria as part of diagnosis. Cytologic findings identified women with bacterial vaginosis and revealed that cytolysis of vaginal epithelial cells is associated to Lactobacillus crispatus-dominated microbiota. Education and socio-economic status were associated to the vaginal microbiota variation. Our results highlight the importance of including socio-economic status as a co-factor in future vaginal microbiota studies.
Subject: BACTERIAL VAGINOSIS
AEROBIC VAGINITIS
RISK-FACTORS
WOMEN
3123 Gynaecology and paediatrics
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_019_44157_8.pdf 2.159Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record