Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)

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Langat , M , Helfenstein , A , Horner , C , Tammela , P , Hokkanen , H , Izotov , D & Mulholland , D 2018 , ' Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae) ' , Chemistry & Biodiversity , vol. 15 , no. 10 , e1800056 . https://doi.org/10.1002/cbdv.201800056

Title: Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)
Author: Langat, Moses; Helfenstein, Andreas; Horner, Claire; Tammela, Päivi; Hokkanen, Heikki; Izotov, Denis; Mulholland, Dulcie
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Heikki Hokkanen / Principal Investigator
Date: 2018-07-03
Language: eng
Number of pages: 7
Belongs to series: Chemistry & Biodiversity
ISSN: 1612-1872
URI: http://hdl.handle.net/10138/303737
Abstract: Pumilol (1), a strobane diterpenoid, reported herein for the first time, was isolated from the bark of Pinus pumila (Pall.) Regel (Siberian Dwarf Pine or Japanese Stone Pine), along with 17 known compounds including serratane triterpenoids, not previously reported from this species, and four ferulate derivatives. The absolute configuration of pumilolwas established using HR-ESI-MS, NMR, the DP4+ probabilities and by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Labda-8(17),13-dien-15-oic acid (4), bornyl (E)-4-hydroxycinnamate (14) and bornyl (E)-ferulate (15) showed activity against S.aureus and/or E.faecalis with MIC90 values 12.5-50m.
Subject: Pinus pumila
pumilol
strobane
serratane triterpenoid
DP4+probability
electronic circular dichroism
TERPENOIDS
ACID
POPULATIONS
BARK
116 Chemical sciences
317 Pharmacy
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