Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)
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Langat , M , Helfenstein , A , Horner , C , Tammela , P , Hokkanen , H , Izotov , D & Mulholland , D 2018 , ' Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae) ' , Chemistry & Biodiversity , vol. 15 , no. 10 , e1800056 . https://doi.org/10.1002/cbdv.201800056
| Title: | Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae) |
| Author: | Langat, Moses; Helfenstein, Andreas; Horner, Claire; Tammela, Päivi; Hokkanen, Heikki; Izotov, Denis; Mulholland, Dulcie |
| Contributor organization: | Faculty of Pharmacy Division of Pharmaceutical Biosciences Bioactivity Screening Group Drug Research Program Heikki Hokkanen / Principal Investigator Department of Agricultural Sciences |
| Date: | 2018-07-03 |
| Language: | eng |
| Number of pages: | 7 |
| Belongs to series: | Chemistry & Biodiversity |
| ISSN: | 1612-1872 |
| DOI: | https://doi.org/10.1002/cbdv.201800056 |
| URI: | http://hdl.handle.net/10138/303737 |
| Abstract: | Pumilol (1), a strobane diterpenoid, reported herein for the first time, was isolated from the bark of Pinus pumila (Pall.) Regel (Siberian Dwarf Pine or Japanese Stone Pine), along with 17 known compounds including serratane triterpenoids, not previously reported from this species, and four ferulate derivatives. The absolute configuration of pumilolwas established using HR-ESI-MS, NMR, the DP4+ probabilities and by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Labda-8(17),13-dien-15-oic acid (4), bornyl (E)-4-hydroxycinnamate (14) and bornyl (E)-ferulate (15) showed activity against S.aureus and/or E.faecalis with MIC90 values 12.5-50m. |
| Subject: |
Pinus pumila
pumilol strobane serratane triterpenoid DP4+probability electronic circular dichroism TERPENOIDS ACID POPULATIONS BARK 116 Chemical sciences 317 Pharmacy |
| Peer reviewed: | Yes |
| Usage restriction: | openAccess |
| Self-archived version: | acceptedVersion |
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