Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)

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Langat , M , Helfenstein , A , Horner , C , Tammela , P , Hokkanen , H , Izotov , D & Mulholland , D 2018 , ' Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae) ' , Chemistry & Biodiversity , vol. 15 , no. 10 , e1800056 . https://doi.org/10.1002/cbdv.201800056

Title: Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)
Author: Langat, Moses; Helfenstein, Andreas; Horner, Claire; Tammela, Päivi; Hokkanen, Heikki; Izotov, Denis; Mulholland, Dulcie
Contributor organization: Faculty of Pharmacy
Division of Pharmaceutical Biosciences
Bioactivity Screening Group
Drug Research Program
Heikki Hokkanen / Principal Investigator
Department of Agricultural Sciences
Date: 2018-07-03
Language: eng
Number of pages: 7
Belongs to series: Chemistry & Biodiversity
ISSN: 1612-1872
DOI: https://doi.org/10.1002/cbdv.201800056
URI: http://hdl.handle.net/10138/303737
Abstract: Pumilol (1), a strobane diterpenoid, reported herein for the first time, was isolated from the bark of Pinus pumila (Pall.) Regel (Siberian Dwarf Pine or Japanese Stone Pine), along with 17 known compounds including serratane triterpenoids, not previously reported from this species, and four ferulate derivatives. The absolute configuration of pumilolwas established using HR-ESI-MS, NMR, the DP4+ probabilities and by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Labda-8(17),13-dien-15-oic acid (4), bornyl (E)-4-hydroxycinnamate (14) and bornyl (E)-ferulate (15) showed activity against S.aureus and/or E.faecalis with MIC90 values 12.5-50m.
Subject: Pinus pumila
serratane triterpenoid
electronic circular dichroism
116 Chemical sciences
317 Pharmacy
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion

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