Simple 3D printed stainless steel microreactors for online mass spectrometric analysis

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http://hdl.handle.net/10138/303758

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Scotti , G , Nilsson , S M E , Matilainen , V-P , Haapala , M , Boije af Gennäs , G , Yli-Kauhaluoma , J , Salminen , A & Kotiaho , T 2019 , ' Simple 3D printed stainless steel microreactors for online mass spectrometric analysis ' , Heliyon , vol. 5 , no. 7 , 02002 . https://doi.org/10.1016/j.heliyon.2019.e02002

Title: Simple 3D printed stainless steel microreactors for online mass spectrometric analysis
Author: Scotti, Gianmario; Nilsson, Sofia M.E.; Matilainen, Ville-Pekka; Haapala, Markus; Boije af Gennäs, Gustav; Yli-Kauhaluoma, Jari; Salminen, Antti; Kotiaho, Tapio
Contributor organization: Division of Pharmaceutical Chemistry and Technology
Faculty of Pharmacy
Drug Research Program
Pharmaceutical Design and Discovery group
Jari Yli-Kauhaluoma / Principal Investigator
Tapio Kotiaho / Principal Investigator
Department of Chemistry
Tiina Sikanen / Chemical Microsystems Lab
Date: 2019-07-02
Language: eng
Number of pages: 7
Belongs to series: Heliyon
ISSN: 2405-8440
DOI: https://doi.org/10.1016/j.heliyon.2019.e02002
URI: http://hdl.handle.net/10138/303758
Abstract: A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreactor was investigated by using an inverse electron demand Diels-Alder and subsequent retro Diels-Alder reaction for testing. Challenges and problems encountered are discussed and improvements proposed. Adsorption of reagents to the rough stainless steel channel walls, short length of the reaction channel, and making a proper ESI tip present challenges, but the microreactor is potentially useful as a disposable device.
Subject: 116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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