Cognitive ability in young adulthood predicts risk of early-onset dementia in Finnish men

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http://hdl.handle.net/10138/303798

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Rantalainen , V , Lahti , J , Henriksson , M , Kajantie , E , Eriksson , J G & Räikkönen , K 2018 , ' Cognitive ability in young adulthood predicts risk of early-onset dementia in Finnish men ' , Neurology , vol. 91 , no. 2 , pp. e171-e179 . https://doi.org/10.1212/WNL.0000000000005757

Title: Cognitive ability in young adulthood predicts risk of early-onset dementia in Finnish men
Author: Rantalainen, Ville; Lahti, Jari; Henriksson, Markus; Kajantie, Eero; Eriksson, Johan G.; Räikkönen, Katri
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Lastentautien yksikkö
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Medicum
Date: 2018-07-10
Language: eng
Number of pages: 9
Belongs to series: Neurology
ISSN: 0028-3878
URI: http://hdl.handle.net/10138/303798
Abstract: Objective To test if the Finnish Defence Forces Basic Intellectual Ability Test scores at 20.1 years predicted risk of organic dementia or Alzheimer disease (AD). Methods Dementia was defined as inpatient or outpatient diagnosis of organic dementia or AD risk derived from Hospital Discharge or Causes of Death Registers in 2,785 men from the Helsinki Birth Cohort Study, divided based on age at first diagnosis into early onset (= 65 years). The Finnish Defence Forces Basic Intellectual Ability Test comprises verbal, arithmetic, and visuospatial subtests and a total score (scores transformed into a mean of 100 and SD of 15). We used Cox proportional hazard models and adjusted for age at testing, childhood socioeconomic status, mother's age at delivery, parity, participant's birthweight, education, and stroke or coronary heart disease diagnosis. Results Lower cognitive ability total and verbal ability (hazard ratio [HR] per 1 SD disadvantage > 1.69, 95% confidence interval [CI] 1.01-2.63) scores predicted higher early-onset any dementia risk across the statistical models; arithmetic and visuospatial ability scores were similarly associated with early-onset any dementia risk, but these associations weakened after covariate adjustments (HR per 1 SD disadvantage > 1.57, 95% CI 0.96-2.57). All associations were rendered non-significant when we adjusted for participant's education. Cognitive ability did not predict late-onset dementia risk. Conclusion These findings reinforce previous suggestions that lower cognitive ability in early life is a risk factor for early-onset dementia.
Subject: 515 Psychology
3112 Neurosciences
3124 Neurology and psychiatry
LATE-LIFE
ALZHEIMERS-DISEASE
GROWTH
CHILDHOOD
COHORT
TRAJECTORIES
INTELLIGENCE
STABILITY
CHILDREN
BRAIN
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