Effect of Albumin in Combination With Mannitol on Whole-blood Coagulation In Vitro Assessed by Thromboelastometry

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Lillemae , K , Laine , A T , Schramko , A & Niemi , T T 2018 , ' Effect of Albumin in Combination With Mannitol on Whole-blood Coagulation In Vitro Assessed by Thromboelastometry ' , Journal of Neurosurgical Anesthesiology , vol. 30 , no. 3 , pp. 265-272 . https://doi.org/10.1097/ANA.0000000000000438

Title: Effect of Albumin in Combination With Mannitol on Whole-blood Coagulation In Vitro Assessed by Thromboelastometry
Author: Lillemae, Kadri; Laine, Antti T.; Schramko, Alexey; Niemi, Tomi T.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-07
Language: eng
Number of pages: 8
Belongs to series: Journal of Neurosurgical Anesthesiology
ISSN: 0898-4921
URI: http://hdl.handle.net/10138/303849
Abstract: Background:Albumin and mannitol may interfere with hemostasis, but their coinfluence is unclear. We aimed to determine the effects of albumin alone and in combination with mannitol or Ringer acetate (RAC) on hemostasis in crossover in vitro study.Materials and Methods:From citrated fresh whole blood withdrawn from 10 volunteers, we prepared 2.5, 5, 10, 15, and 20 vol% dilutions of 4% albumin (Alb group). Each sample was thereafter diluted by 15% mannitol (Alb/Man group) or RAC (Alb/RAC group) at a ratio of 9:1. Using thromboelastometry, FibTEM (fibrinogen ROTEM) and ExTEM (extrinsic ROTEM) tests were performed.Results:A 20 vol%, but not 2.5 to 15 vol% dilution of albumin caused a prolonged clot formation time, -angle decrease, and maximum clot firmness (MCF) weakening compared with undiluted sample (P
Subject: albumin
mannitol
Ringer acetate
RAC
thromboelastometry
TEG
neurosurgery
neuroanesthesiology
blood coagulation
TRAUMATIC BRAIN-INJURY
HYDROXYETHYL STARCH
HYPERTONIC SALINE
ARTIFICIAL COLLOIDS
PLATELET-FUNCTION
HEMODILUTION
RESUSCITATION
HEMOSTASIS
PRESSURE
3126 Surgery, anesthesiology, intensive care, radiology
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