Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology

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Henningsen , A-K A , Bergh , C , Skjaerven , R , Tiitinen , A , Wennerholm , U-B , Romundstad , L B , Gissler , M , Opdahl , S , Andersen , A N , Lidegaard , O , Forman , J L & Pinborg , A 2018 , ' Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 97 , no. 7 , pp. 816-823 . https://doi.org/10.1111/aogs.13347

Title: Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology
Author: Henningsen, Anna-Karina A.; Bergh, Christina; Skjaerven, Rolv; Tiitinen, Aila; Wennerholm, Ulla-Britt; Romundstad, Liv B.; Gissler, Mika; Opdahl, Signe; Andersen, Anders Nyboe; Lidegaard, Ojvind; Forman, Julie L.; Pinborg, Anja
Other contributor: University of Helsinki, Clinicum


Date: 2018-07
Language: eng
Number of pages: 8
Belongs to series: Acta Obstetricia et Gynecologica Scandinavica
ISSN: 0001-6349
DOI: https://doi.org/10.1111/aogs.13347
URI: http://hdl.handle.net/10138/303876
Abstract: IntroductionChildren born after assisted reproductive technology, particularly singletons, have been shown to have an increased risk of congenital malformations compared with children born after spontaneous conception. We wished to study whether there has been a change in the past 20 years in the risk of major congenital malformations in children conceived after assisted reproductive technology compared with children spontaneously conceived. Material and methodsPopulation-based cohort study including 90 201 assisted reproductive technology children and 482 552 children spontaneously conceived, born in Denmark, Finland, Norway and Sweden. Both singletons and twins born after in vitro fertilization, intracytoplasmatic sperm injection and frozen embryo transfer were included. Data on children were taken from when the national Nordic assisted reproductive technology registries were established until 2007. Multiple logistic regression analyses were used to estimate the risks and adjusted odds ratios for congenital malformations in four time periods: 1988-1992, 1993-1997, 1998-2002 and 2003-2007. Only major malformations were included. ResultsThe absolute risk for singletons of being born with a major malformation was 3.4% among assisted reproductive technology children vs. 2.9% among children spontaneously conceived during the study period. The relative risk of being born with a major congenital malformation between all assisted reproductive technology children and children spontaneously conceived remained similar through all four time periods (p = 0.39). However, we found that over time the number of children diagnosed with a major malformation increased in both groups across all four time periods. ConclusionWhen comparing children conceived after assisted reproductive technology and spontaneously conceived, the relative risk of being born with a major congenital malformation did not change during the study period.
Subject: Assisted reproduction
congenital malformations
trends
subfertility
perinatal outcome
IN-VITRO FERTILIZATION
BIRTH-DEFECTS
CONARTAS GROUP
INFANTS BORN
RISK
METAANALYSIS
PREGNANCY
DIAGNOSIS
ANOMALIES
SWEDEN
3123 Gynaecology and paediatrics
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