Family history influences the tumor characteristics and prognosis of breast cancers developing during postmenopausal hormone therapy

Show simple item record Fagerholm, Rainer Faltinova, Maria Aaltonen, Kirsi Aittomaki, Kristiina Heikkila, Paivi Halttunen-Nieminen, Mervi Nevanlinna, Heli Blomqvist, Carl 2019-07-10T21:49:30Z 2019-07-10T21:49:30Z 2018-07
dc.identifier.citation Fagerholm , R , Faltinova , M , Aaltonen , K , Aittomaki , K , Heikkila , P , Halttunen-Nieminen , M , Nevanlinna , H & Blomqvist , C 2018 , ' Family history influences the tumor characteristics and prognosis of breast cancers developing during postmenopausal hormone therapy ' , Familial Cancer , vol. 17 , no. 3 , pp. 321-331 .
dc.identifier.other PURE: 109133277
dc.identifier.other PURE UUID: d35976ce-a818-4289-af69-7e5c10f1f5b0
dc.identifier.other WOS: 000435355800002
dc.identifier.other Scopus: 85030861321
dc.description.abstract Long term use of postmenopausal hormone therapy (HT) has been reported to increase breast cancer risk. On the other hand, observational studies suggest that breast cancers diagnosed during HT may have a more favorable prognosis. While family history is a risk factor for breast cancer, and genetic factors also influence prognosis, the role of family history in combination with HT use has been little studied. We investigated the relationship between HT, family history, and prognosis in 584 (267 exposed) familial and 952 (460 exposed) non-familial breast cancer cases, using three survival end points: death from breast cancer (BCS), distant disease free survival (DDFS), and local recurrence free survival (LRFS). Among non-familial cases, HT was associated with better BCS (HR 0.63, 95% CI 0.41-0.94; p = 0.025), and DDFS (HR 0.58, 95% CI 0.40-0.85; p = 0.005), with a consistent but not statistically significant effect in LRFS. This effect was not seen in familial cases (HR > 1.0), and family history was found to interact with HT in BCS (p((interaction)) = 0.0067) (BC-death) and DDFS (p((interaction)) = 0.0070). There was phenotypic heterogeneity between HT-associated tumors in familial and non-familial cases, particularly on estrogen receptor (ER) status, although the interaction between HT and family history appears to be at least partially independent of these markers (p = 0.0370 after adjustment for standard prognostic factors). If confirmed by further studies, our results suggest that family history should be taken into consideration in clinical counseling before beginning a HT regimen. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Familial Cancer
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Hormone replacement therapy
dc.subject Breast cancer
dc.subject Family history
dc.subject Survival
dc.subject Prognosis
dc.subject Observational study
dc.subject BRCA2 MUTATIONS
dc.subject FOLLOW-UP
dc.subject WOMEN
dc.subject RISK
dc.subject MORTALITY
dc.subject EXPRESSION
dc.subject CARCINOMA
dc.subject DIAGNOSIS
dc.subject 3122 Cancers
dc.title Family history influences the tumor characteristics and prognosis of breast cancers developing during postmenopausal hormone therapy en
dc.type Article
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization Clinicum
dc.contributor.organization Department of Oncology
dc.contributor.organization Medicum
dc.contributor.organization Kristiina Aittomäki / Principal Investigator
dc.contributor.organization Department of Medical and Clinical Genetics
dc.contributor.organization Department of Pathology
dc.contributor.organization HUS Gynecology and Obstetrics
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Teachers' Academy
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1389-9600
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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