Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density and fine particle levels

Show full item record



Permalink

http://hdl.handle.net/10138/303940

Citation

Mäkelä , K , Ollila , H , Sutinen , E , Vuorinen , V , Peltola , E , Kaarteenaho , R & Myllärniemi , M 2019 , ' Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density and fine particle levels ' , Annals of diagnostic pathology , vol. 40 , pp. 136-142 . https://doi.org/10.1016/j.anndiagpath.2019.04.011

Title: Inorganic particulate matter in the lung tissue of idiopathic pulmonary fibrosis patients reflects population density and fine particle levels
Author: Mäkelä, Kati; Ollila, Hely; Sutinen, Eva; Vuorinen, Vesa; Peltola, Emilia; Kaarteenaho, Riitta; Myllärniemi, Marjukka
Contributor: University of Helsinki, INDIVIDRUG - Individualized Drug Therapy
University of Helsinki, INDIVIDRUG - Individualized Drug Therapy
University of Helsinki, INDIVIDRUG - Individualized Drug Therapy
University of Helsinki, INDIVIDRUG - Individualized Drug Therapy
Date: 2019-06
Language: eng
Number of pages: 7
Belongs to series: Annals of diagnostic pathology
ISSN: 1092-9134
URI: http://hdl.handle.net/10138/303940
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a dismal prognosis and an unknown etiology. Inorganic dust is a known risk factor, and air pollution seems to affect disease progression. We aimed to investigate inorganic particulate matter in IPF lung tissue samples. Using polarizing light microscopy, we examined coal dust pigment and inorganic particulate matter in 73 lung tissue samples from the FinnishIPF registry. We scored the amount of coal dust pigment and particulate matter from 0 to 5. Using energy dispersive spectrometry with a scanning electron microscope, we conducted an elemental analysis of six IPF lung tissue samples. We compared the results to the registry data, and to the population density and air quality data. To compare categorical data, we used Fisher's exact test; we estimated the survival of the patients with Kaplan-Meier curves. We found inorganic particulate matter in all samples in varying amounts. Samples from the southern regions of Finland, where population density and fine particle levels are high, more often had particulate matter scores from 3 to 5 than samples from the northern regions (31/50, 62.0% vs. 7/23, 30.4%, p = 0.02). The highest particulate matter scores of 4 and 5 (n = 15) associated with a known exposure to inorganic dust (p = 0.004). An association between particulate matter in the lung tissue of IPF patients and exposure to air pollution may exist.
Subject: Idiopathic pulmonary fibrosis
Usual interstitial pneumonia
Particulate matter
Air pollution
Polarizing light microscopy
Scanning electron microscopy
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S109291341930125X_main_1.pdf 866.1Kb PDF View/Open
1_s2.0_S109291341930125X_main.pdf 4.805Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record