Quality of life and depression 3 months after intracerebral hemorrhage

Show full item record



Permalink

http://hdl.handle.net/10138/303946

Citation

Sallinen , H , Sairanen , T & Strbian , D 2019 , ' Quality of life and depression 3 months after intracerebral hemorrhage ' , Brain and Behavior , vol. 9 , no. 5 , 01270 . https://doi.org/10.1002/brb3.1270

Title: Quality of life and depression 3 months after intracerebral hemorrhage
Author: Sallinen, Hanne; Sairanen, Tiina; Strbian, Daniel
Contributor: University of Helsinki, Neurologian yksikkö
University of Helsinki, Perttu Lindsberg / Principal Investigator
University of Helsinki, Neurologian yksikkö
Date: 2019-05
Language: eng
Number of pages: 10
Belongs to series: Brain and Behavior
ISSN: 2162-3279
URI: http://hdl.handle.net/10138/303946
Abstract: Objectives: Quality of life (QoL) after intracerebral hemorrhage (ICH) is poorly known. This study investigated factors affecting QoL and depression after spontaneous ICH. Materials and Methods: This prospective study included patients admitted to Helsinki University Hospital between May 2014 and December 2016. Health-related QoL (HRQoL) at 3 months after ICH was measured using the European Quality of Life Scale (EQ-5D-5L), and the 15D scale. Logistic regression analyses were used to test factors affecting HRQoL. EQ-5D-5L anxiety/depression dimension was used to analyze factors associated with anxiety/depression. Results: Of 277 patients, 220 were alive, and sent QoL questionnaire. The questionnaire was returned by 124 patients. Nonreturners had more severe strokes with admission National Institutes of Health Stroke Scale (NIHSS) 7.8 (IQR 3.0-14.8) versus 5.0 (IQR 2.3-11.0); p = 0.018, and worse outcome assessed as modified Rankin Scale 3-5 at 3 months 59.4% versus 44.4% (p = 0.030). Predictors for lower HRQoL by both scales were higher NIHSS with OR 1.28 (95% CI 1.13-1.46) for EQ-5D-5L, and OR 1.28 (1.15-1.44) for 15D, older age (OR 1.10 [1.03-1.16], and OR 1.09 [1.03-1.15]), and chronic heart failure (OR 18.12 [1.73-189.27], and OR 12.84 [1.31126.32]), respectively. Feeling sad/depressed for more than 2 weeks during the year prior to ICH was predictor for lower EQ-5D-5L (OR 10.64 [2.39-47.28]), and history of ICH for lower 15D utility indexes (OR 11.85 [1.01-138.90]). Prior feelings of sadness/ depression were associated with depression/anxiety at 3 months after ICH with OR 3.62 (1.14-11.45). Conclusions: In this cohort of ICH patients with milder deficits, HRQoL was affected by stroke severity, comorbidities and age. Feelings of depression before ICH had stronger influence on reporting depression/anxiety after ICH than stroke severity-related and outcome parameters. Thus, simple questions on patient's premorbid feelings of sadness/depression could be used to identify patients at risk of depression after ICH for focusing follow-up and treatment.
Subject: depression
intracerebral hemorrhage
quality of life
ISCHEMIC-STROKE PATIENTS
LONG-TERM SURVIVORS
MOOD
3112 Neurosciences
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Sallinen_et_al_2019_Brain_and_Behavior.pdf 428.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record