Quality of life and depression 3 months after intracerebral hemorrhage

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dc.contributor University of Helsinki, Neurologian yksikkö en
dc.contributor University of Helsinki, Perttu Lindsberg / Principal Investigator en
dc.contributor University of Helsinki, Neurologian yksikkö en
dc.contributor.author Sallinen, Hanne
dc.contributor.author Sairanen, Tiina
dc.contributor.author Strbian, Daniel
dc.date.accessioned 2019-07-19T05:57:01Z
dc.date.available 2019-07-19T05:57:01Z
dc.date.issued 2019-05
dc.identifier.citation Sallinen , H , Sairanen , T & Strbian , D 2019 , ' Quality of life and depression 3 months after intracerebral hemorrhage ' , Brain and Behavior , vol. 9 , no. 5 , 01270 . https://doi.org/10.1002/brb3.1270 en
dc.identifier.issn 2162-3279
dc.identifier.other PURE: 125766359
dc.identifier.other PURE UUID: 10773f51-55e5-4411-8285-350b430a2005
dc.identifier.other WOS: 000471349100009
dc.identifier.uri http://hdl.handle.net/10138/303946
dc.description.abstract Objectives: Quality of life (QoL) after intracerebral hemorrhage (ICH) is poorly known. This study investigated factors affecting QoL and depression after spontaneous ICH. Materials and Methods: This prospective study included patients admitted to Helsinki University Hospital between May 2014 and December 2016. Health-related QoL (HRQoL) at 3 months after ICH was measured using the European Quality of Life Scale (EQ-5D-5L), and the 15D scale. Logistic regression analyses were used to test factors affecting HRQoL. EQ-5D-5L anxiety/depression dimension was used to analyze factors associated with anxiety/depression. Results: Of 277 patients, 220 were alive, and sent QoL questionnaire. The questionnaire was returned by 124 patients. Nonreturners had more severe strokes with admission National Institutes of Health Stroke Scale (NIHSS) 7.8 (IQR 3.0-14.8) versus 5.0 (IQR 2.3-11.0); p = 0.018, and worse outcome assessed as modified Rankin Scale 3-5 at 3 months 59.4% versus 44.4% (p = 0.030). Predictors for lower HRQoL by both scales were higher NIHSS with OR 1.28 (95% CI 1.13-1.46) for EQ-5D-5L, and OR 1.28 (1.15-1.44) for 15D, older age (OR 1.10 [1.03-1.16], and OR 1.09 [1.03-1.15]), and chronic heart failure (OR 18.12 [1.73-189.27], and OR 12.84 [1.31126.32]), respectively. Feeling sad/depressed for more than 2 weeks during the year prior to ICH was predictor for lower EQ-5D-5L (OR 10.64 [2.39-47.28]), and history of ICH for lower 15D utility indexes (OR 11.85 [1.01-138.90]). Prior feelings of sadness/ depression were associated with depression/anxiety at 3 months after ICH with OR 3.62 (1.14-11.45). Conclusions: In this cohort of ICH patients with milder deficits, HRQoL was affected by stroke severity, comorbidities and age. Feelings of depression before ICH had stronger influence on reporting depression/anxiety after ICH than stroke severity-related and outcome parameters. Thus, simple questions on patient's premorbid feelings of sadness/depression could be used to identify patients at risk of depression after ICH for focusing follow-up and treatment. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Brain and Behavior
dc.rights en
dc.subject depression en
dc.subject intracerebral hemorrhage en
dc.subject quality of life en
dc.subject MOOD en
dc.subject 3112 Neurosciences en
dc.subject 3124 Neurology and psychiatry en
dc.title Quality of life and depression 3 months after intracerebral hemorrhage en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1002/brb3.1270
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion

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