Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

Show simple item record Sartelli, Massimo Abu-Zidan, Fikri M Labricciosa, Francesco M Kluger, Yoram Coccolini, Federico Ansaloni, Luca Leppäniemi, Ari Kirkpatrick, Andrew W Tolonen, Matti Tranà, Cristian Regimbeau, Jean-Marc Hardcastle, Timothy Koshy, Renol M Abbas, Ashraf Aday, Ulaş Adesunkanmi, A. R K Ajibade, Adesina Akhmeteli, Lali Akın, Emrah Akkapulu, Nezih Alotaibi, Alhenouf Altintoprak, Fatih Anyfantakis, Dimitrios Atanasov, Boyko Augustin, Goran Azevedo, Constança Bala, Miklosh Balalis, Dimitrios Baraket, Oussama Baral, Suman Barkai, Or Beltran, Marcelo Bini, Roberto Bouliaris, Konstantinos Caballero, Ana B Calu, Valentin Catani, Marco Ceresoli, Marco Charalampakis, Vasileios Jusoh, Asri C Chiarugi, Massimo Cillara, Nicola Cuesta, Raquel C Cobuccio, Luigi Cocorullo, Gianfranco Colak, Elif Conti, Luigi Cui, Yunfeng De Simone, Belinda Delibegovic, Samir Demetrashvili, Zaza Demetriades, Demetrios Dimova, Ana Dogjani, Agron Enani, Mushira Farina, Federica Ferrara, Francesco Foghetti, Domitilla Fontana, Tommaso Fraga, Gustavo P Gachabayov, Mahir Gérard, Grelpois Ghnnam, Wagih Maurel, Teresa G Gkiokas, Georgios Gomes, Carlos A Guner, Ali Gupta, Sanjay Hecker, Andreas Hirano, Elcio S Hodonou, Adrien Hutan, Martin Ilaschuk, Igor Ioannidis, Orestis Isik, Arda Ivakhov, Georgy Jain, Sumita Jokubauskas, Mantas Karamarkovic, Aleksandar Kaushik, Robin Kenig, Jakub Khokha, Vladimir Khokha, Denis Kim, Jae I Kong, Victor Korkolis, Dimitris Kruger, Vitor F Kshirsagar, Ashok Simões, Romeo L Lanaia, Andrea Lasithiotakis, Konstantinos Leão, Pedro Arellano, Miguel L Listle, Holger Litvin, Andrey Lizarazu Pérez, Aintzane Lopez-Tomassetti Fernandez, Eudaldo Lostoridis, Eftychios Luppi, Davide Machain V, Gustavo M Major, Piotr Manatakis, Dimitrios Reitz, Marianne M Marinis, Athanasios Marrelli, Daniele Martínez-Pérez, Aleix Marwah, Sanjay McFarlane, Michael Mesic, Mirza Mesina, Cristian Michalopoulos, Nickos Misiakos, Evangelos Moreira, Felipe G Mouaqit, Ouadii Muhtaroglu, Ali Naidoo, Noel Negoi, Ionut Nikitina, Zane Nikolopoulos, Ioannis Nita, Gabriela-Elisa Occhionorelli, Savino Olaoye, Iyiade Ordoñez, Carlos A Ozkan, Zeynep Pal, Ajay Palini, Gian M Papageorgiou, Kyriaki Papagoras, Dimitris Pata, Francesco Pędziwiatr, Michał Pereira, Jorge Pereira Junior, Gerson A Perrone, Gennaro Pintar, Tadeja Pisarska, Magdalena Plehutsa, Oleksandr Podda, Mauro Poillucci, Gaetano Quiodettis, Martha Rahim, Tuba Rios-Cruz, Daniel Rodrigues, Gabriel Rozov, Dmytry Sakakushev, Boris Sall, Ibrahima Sazhin, Alexander Semião, Miguel Sharda, Taanya Shelat, Vishal Sinibaldi, Giovanni Skicko, Dmitrijs Skrovina, Matej Stamatiou, Dimitrios Stella, Marco Strzałka, Marcin Sydorchuk, Ruslan Teixeira Gonsaga, Ricardo A Tochie, Joel N Tomadze, Gia Ugoletti, Lara Ulrych, Jan Ümarik, Toomas Uzunoglu, Mustafa Y Vasilescu, Alin Vaz, Osborne Vereczkei, Andras Vlad, Nutu Walędziak, Maciej Yahya, Ali I Yalkin, Omer Yilmaz, Tonguç U Ünal, Ali E Yuan, Kuo-Ching Zachariah, Sanoop K Žilinskas, Justas Zizzo, Maurizio Pattonieri, Vittoria Baiocchi, Gian L Catena, Fausto 2019-07-21T03:31:49Z 2019-07-21T03:31:49Z 2019-07-15
dc.identifier.citation World Journal of Emergency Surgery. 2019 Jul 15;14(1):34
dc.description.abstract Abstract Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
dc.publisher BioMed Central
dc.subject Acute peritonitis
dc.subject Source control
dc.subject Early warning score
dc.subject Emergency surgery
dc.title Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study 2019-07-21T03:31:49Z
dc.language.rfc3066 en
dc.rights.holder The Author(s).

Files in this item

Total number of downloads: Loading...

Files Size Format View
13017_2019_Article_253.pdf 669.8Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record