Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

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dc.contributor.author Sartelli, Massimo
dc.contributor.author Abu-Zidan, Fikri M
dc.contributor.author Labricciosa, Francesco M
dc.contributor.author Kluger, Yoram
dc.contributor.author Coccolini, Federico
dc.contributor.author Ansaloni, Luca
dc.contributor.author Leppäniemi, Ari
dc.contributor.author Kirkpatrick, Andrew W
dc.contributor.author Tolonen, Matti
dc.contributor.author Tranà, Cristian
dc.contributor.author Regimbeau, Jean-Marc
dc.contributor.author Hardcastle, Timothy
dc.contributor.author Koshy, Renol M
dc.contributor.author Abbas, Ashraf
dc.contributor.author Aday, Ulaş
dc.contributor.author Adesunkanmi, A. R K
dc.contributor.author Ajibade, Adesina
dc.contributor.author Akhmeteli, Lali
dc.contributor.author Akın, Emrah
dc.contributor.author Akkapulu, Nezih
dc.contributor.author Alotaibi, Alhenouf
dc.contributor.author Altintoprak, Fatih
dc.contributor.author Anyfantakis, Dimitrios
dc.contributor.author Atanasov, Boyko
dc.contributor.author Augustin, Goran
dc.contributor.author Azevedo, Constança
dc.contributor.author Bala, Miklosh
dc.contributor.author Balalis, Dimitrios
dc.contributor.author Baraket, Oussama
dc.contributor.author Baral, Suman
dc.contributor.author Barkai, Or
dc.contributor.author Beltran, Marcelo
dc.contributor.author Bini, Roberto
dc.contributor.author Bouliaris, Konstantinos
dc.contributor.author Caballero, Ana B
dc.contributor.author Calu, Valentin
dc.contributor.author Catani, Marco
dc.contributor.author Ceresoli, Marco
dc.contributor.author Charalampakis, Vasileios
dc.contributor.author Jusoh, Asri C
dc.contributor.author Chiarugi, Massimo
dc.contributor.author Cillara, Nicola
dc.contributor.author Cuesta, Raquel C
dc.contributor.author Cobuccio, Luigi
dc.contributor.author Cocorullo, Gianfranco
dc.contributor.author Colak, Elif
dc.contributor.author Conti, Luigi
dc.contributor.author Cui, Yunfeng
dc.contributor.author De Simone, Belinda
dc.contributor.author Delibegovic, Samir
dc.contributor.author Demetrashvili, Zaza
dc.contributor.author Demetriades, Demetrios
dc.contributor.author Dimova, Ana
dc.contributor.author Dogjani, Agron
dc.contributor.author Enani, Mushira
dc.contributor.author Farina, Federica
dc.contributor.author Ferrara, Francesco
dc.contributor.author Foghetti, Domitilla
dc.contributor.author Fontana, Tommaso
dc.contributor.author Fraga, Gustavo P
dc.contributor.author Gachabayov, Mahir
dc.contributor.author Gérard, Grelpois
dc.contributor.author Ghnnam, Wagih
dc.contributor.author Maurel, Teresa G
dc.contributor.author Gkiokas, Georgios
dc.contributor.author Gomes, Carlos A
dc.contributor.author Guner, Ali
dc.contributor.author Gupta, Sanjay
dc.contributor.author Hecker, Andreas
dc.contributor.author Hirano, Elcio S
dc.contributor.author Hodonou, Adrien
dc.contributor.author Hutan, Martin
dc.contributor.author Ilaschuk, Igor
dc.contributor.author Ioannidis, Orestis
dc.contributor.author Isik, Arda
dc.contributor.author Ivakhov, Georgy
dc.contributor.author Jain, Sumita
dc.contributor.author Jokubauskas, Mantas
dc.contributor.author Karamarkovic, Aleksandar
dc.contributor.author Kaushik, Robin
dc.contributor.author Kenig, Jakub
dc.contributor.author Khokha, Vladimir
dc.contributor.author Khokha, Denis
dc.contributor.author Kim, Jae I
dc.contributor.author Kong, Victor
dc.contributor.author Korkolis, Dimitris
dc.contributor.author Kruger, Vitor F
dc.contributor.author Kshirsagar, Ashok
dc.contributor.author Simões, Romeo L
dc.contributor.author Lanaia, Andrea
dc.contributor.author Lasithiotakis, Konstantinos
dc.contributor.author Leão, Pedro
dc.contributor.author Arellano, Miguel L
dc.contributor.author Listle, Holger
dc.contributor.author Litvin, Andrey
dc.contributor.author Lizarazu Pérez, Aintzane
dc.contributor.author Lopez-Tomassetti Fernandez, Eudaldo
dc.contributor.author Lostoridis, Eftychios
dc.contributor.author Luppi, Davide
dc.contributor.author Machain V, Gustavo M
dc.contributor.author Major, Piotr
dc.contributor.author Manatakis, Dimitrios
dc.contributor.author Reitz, Marianne M
dc.contributor.author Marinis, Athanasios
dc.contributor.author Marrelli, Daniele
dc.contributor.author Martínez-Pérez, Aleix
dc.contributor.author Marwah, Sanjay
dc.contributor.author McFarlane, Michael
dc.contributor.author Mesic, Mirza
dc.contributor.author Mesina, Cristian
dc.contributor.author Michalopoulos, Nickos
dc.contributor.author Misiakos, Evangelos
dc.contributor.author Moreira, Felipe G
dc.contributor.author Mouaqit, Ouadii
dc.contributor.author Muhtaroglu, Ali
dc.contributor.author Naidoo, Noel
dc.contributor.author Negoi, Ionut
dc.contributor.author Nikitina, Zane
dc.contributor.author Nikolopoulos, Ioannis
dc.contributor.author Nita, Gabriela-Elisa
dc.contributor.author Occhionorelli, Savino
dc.contributor.author Olaoye, Iyiade
dc.contributor.author Ordoñez, Carlos A
dc.contributor.author Ozkan, Zeynep
dc.contributor.author Pal, Ajay
dc.contributor.author Palini, Gian M
dc.contributor.author Papageorgiou, Kyriaki
dc.contributor.author Papagoras, Dimitris
dc.contributor.author Pata, Francesco
dc.contributor.author Pędziwiatr, Michał
dc.contributor.author Pereira, Jorge
dc.contributor.author Pereira Junior, Gerson A
dc.contributor.author Perrone, Gennaro
dc.contributor.author Pintar, Tadeja
dc.contributor.author Pisarska, Magdalena
dc.contributor.author Plehutsa, Oleksandr
dc.contributor.author Podda, Mauro
dc.contributor.author Poillucci, Gaetano
dc.contributor.author Quiodettis, Martha
dc.contributor.author Rahim, Tuba
dc.contributor.author Rios-Cruz, Daniel
dc.contributor.author Rodrigues, Gabriel
dc.contributor.author Rozov, Dmytry
dc.contributor.author Sakakushev, Boris
dc.contributor.author Sall, Ibrahima
dc.contributor.author Sazhin, Alexander
dc.contributor.author Semião, Miguel
dc.contributor.author Sharda, Taanya
dc.contributor.author Shelat, Vishal
dc.contributor.author Sinibaldi, Giovanni
dc.contributor.author Skicko, Dmitrijs
dc.contributor.author Skrovina, Matej
dc.contributor.author Stamatiou, Dimitrios
dc.contributor.author Stella, Marco
dc.contributor.author Strzałka, Marcin
dc.contributor.author Sydorchuk, Ruslan
dc.contributor.author Teixeira Gonsaga, Ricardo A
dc.contributor.author Tochie, Joel N
dc.contributor.author Tomadze, Gia
dc.contributor.author Ugoletti, Lara
dc.contributor.author Ulrych, Jan
dc.contributor.author Ümarik, Toomas
dc.contributor.author Uzunoglu, Mustafa Y
dc.contributor.author Vasilescu, Alin
dc.contributor.author Vaz, Osborne
dc.contributor.author Vereczkei, Andras
dc.contributor.author Vlad, Nutu
dc.contributor.author Walędziak, Maciej
dc.contributor.author Yahya, Ali I
dc.contributor.author Yalkin, Omer
dc.contributor.author Yilmaz, Tonguç U
dc.contributor.author Ünal, Ali E
dc.contributor.author Yuan, Kuo-Ching
dc.contributor.author Zachariah, Sanoop K
dc.contributor.author Žilinskas, Justas
dc.contributor.author Zizzo, Maurizio
dc.contributor.author Pattonieri, Vittoria
dc.contributor.author Baiocchi, Gian L
dc.contributor.author Catena, Fausto
dc.date.accessioned 2019-07-21T03:31:49Z
dc.date.available 2019-07-21T03:31:49Z
dc.date.issued 2019-07-15
dc.identifier.citation World Journal of Emergency Surgery. 2019 Jul 15;14(1):34
dc.identifier.uri http://hdl.handle.net/10138/303969
dc.description.abstract Abstract Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
dc.publisher BioMed Central
dc.subject Acute peritonitis
dc.subject Source control
dc.subject Early warning score
dc.subject Emergency surgery
dc.title Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study
dc.date.updated 2019-07-21T03:31:49Z
dc.language.rfc3066 en
dc.rights.holder The Author(s).
dc.type.uri http://purl.org/eprint/entityType/ScholarlyWork
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/type/JournalArticle

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