Heme oxygenase-1 repeat polymorphism in septic acute kidney injury

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http://hdl.handle.net/10138/303971

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FINNAKI Study Grp , Vilander , L M , Vaara , S T , Donner , K M , Lakkisto , P , Kaunisto , M A & Pettilä , V 2019 , ' Heme oxygenase-1 repeat polymorphism in septic acute kidney injury ' , PLoS One , vol. 14 , no. 5 , 0217291 . https://doi.org/10.1371/journal.pone.0217291

Title: Heme oxygenase-1 repeat polymorphism in septic acute kidney injury
Author: FINNAKI Study Grp; Vilander, Laura M.; Vaara, Suvi T.; Donner, Kati M.; Lakkisto, Päivi; Kaunisto, Mari A.; Pettilä, Ville
Contributor: University of Helsinki, Anestesiologian yksikkö
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUSLAB
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUS Perioperative, Intensive Care and Pain Medicine
Date: 2019-05-23
Language: eng
Number of pages: 13
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/303971
Abstract: Acute kidney injury (AKI) is a syndrome that frequently affects the critically ill. Recently, an increased number of dinucleotide repeats in the HMOX1 gene were reported to associate with development of AKI in cardiac surgery. We aimed to test the replicability of this finding in a Finnish cohort of critically ill septic patients. This multicenter study was part of the national FINNAKI study. We genotyped 300 patients with severe AKI (KDIGO 2 or 3) and 353 controls without AKI (KDIGO 0) for the guanine-thymine (GTn) repeat in the promoter region of the HMOX1 gene. The allele calling was based on the number of repeats, the cut off being 27 repeats in the S-L (short to long) classification, and 27 and 34 repeats for the S-M-L2 (short to medium to very long) classification. The plasma concentrations of heme oxygenase-1 (HO-1) enzyme were measured on admission. The allele distribution in our patients was similar to that published previously, with peaks at 23 and 30 repeats. The S-allele increases AKI risk. An adjusted OR was 1.30 for each S-allele in an additive genetic model (95% CI 1.01-1.66; p = 0.041). Alleles with a repeat number greater than 34 were significantly associated with lower HO-1 concentration (p
Subject: GENE PROMOTER
MICROSATELLITE POLYMORPHISM
PLASMA
RISK
HEME-OXYGENASE-1
SUSCEPTIBILITY
INFLAMMATION
ASSOCIATION
FERRITIN
LINKAGE
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
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