Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing

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dc.contributor.author Quarto, Tiziana
dc.contributor.author Paparella, Isabella
dc.contributor.author De Tullio, Davide
dc.contributor.author Viscanti, Ciovanna
dc.contributor.author Fazio, Leonardo
dc.contributor.author Taurisano, Paolo
dc.contributor.author Romano, Raffaella
dc.contributor.author Rampino, Antonio
dc.contributor.author Masellis, Rita
dc.contributor.author Popolizio, Teresa
dc.contributor.author Selvaggi, Pierluigi
dc.contributor.author Pergola, Giulio
dc.contributor.author Bertolino, Alessandro
dc.contributor.author Blasi, Giuseppe
dc.date.accessioned 2019-07-29T21:40:15Z
dc.date.available 2021-12-17T22:45:52Z
dc.date.issued 2018-07
dc.identifier.citation Quarto , T , Paparella , I , De Tullio , D , Viscanti , C , Fazio , L , Taurisano , P , Romano , R , Rampino , A , Masellis , R , Popolizio , T , Selvaggi , P , Pergola , G , Bertolino , A & Blasi , G 2018 , ' Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing ' , Schizophrenia bulletin , vol. 44 , no. 4 , pp. 834-843 . https://doi.org/10.1093/schbul/sbx128
dc.identifier.other PURE: 122635797
dc.identifier.other PURE UUID: 98cc7c9b-53ea-4eef-99be-ee857f7b6f84
dc.identifier.other WOS: 000434861300017
dc.identifier.other Scopus: 85048333146
dc.identifier.uri http://hdl.handle.net/10138/304064
dc.description.abstract The brain functional mechanisms translating genetic risk into emotional symptoms in schizophrenia (SCZ) may include abnormal functional integration between areas key for emotion processing, such as the amygdala and the lateral prefrontal cortex (LPFC). Indeed, investigation of these mechanisms is also complicated by emotion processing comprising different subcomponents and by disease-associated state variables. Here, our aim was to investigate the relationship between risk for SCZ and effective connectivity between the amygdala and the LPFC during different subcomponents of emotion processing. Thus, we first characterized with dynamic causal modeling (DCM) physiological patterns of LPFC amygdala effective connectivity in healthy controls (HC) during implicit and explicit emotion processing. Then, we compared DCM patterns in a subsample of HC, in patients with SCZ and in healthy siblings of patients (SIB), matched for demographics. Finally, we investigated in HC association of LPFC amygdala effective connectivity with a genome-wide supported variant increasing genetic risk for SCZ and possibly relevant to emotion processing (DRD2 rs2514218). In HC, we found that a "bottom-up" amygdala-to-LPFC pattern during implicit processing and a "top-down" LPFC-to-amygdala pattern during explicit processing were the most likely directional models of effective connectivity. Differently, implicit emotion processing in SIB, SCZ, and HC homozygous for the SCZ risk rs2514218 C allele was associated with decreased probability for the "bottom-up" as well as with increased probability for the "top-down" model. These findings suggest that task-specific anomaly in the directional flow of information or disconnection between the amygdala and the LPFC is a good candidate endophenotype of SCZ. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Schizophrenia bulletin
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject endophenotype
dc.subject DRD2 rs2514218
dc.subject dynamic causal model
dc.subject implicit emotion processing
dc.subject explicit emotion processing
dc.subject DIFFERENTIAL NEURAL RESPONSE
dc.subject FACIAL EXPRESSIONS
dc.subject SYNAPTIC PLASTICITY
dc.subject COGNITIVE DYSMETRIA
dc.subject UNAFFECTED SIBLINGS
dc.subject BRAIN ACTIVATION
dc.subject NEGATIVE EMOTION
dc.subject FEAR
dc.subject PSYCHOSIS
dc.subject CORTEX
dc.subject 3124 Neurology and psychiatry
dc.subject 515 Psychology
dc.subject 3111 Biomedicine
dc.title Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing en
dc.type Article
dc.contributor.organization Behavioural Sciences
dc.contributor.organization Elvira Brattico / Principal Investigator
dc.contributor.organization University of Helsinki
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Faculty of Medicine
dc.contributor.organization Cognitive Brain Research Unit
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1093/schbul/sbx128
dc.relation.issn 0586-7614
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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