Reproducibility of corticokinematic coherence

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Piitulainen , H , Illman , M , Laaksonen , K , Jousmäki , V & Forss , N 2018 , ' Reproducibility of corticokinematic coherence ' , NeuroImage , vol. 179 , pp. 596-603 . https://doi.org/10.1016/j.neuroimage.2018.06.078

Title: Reproducibility of corticokinematic coherence
Author: Piitulainen, Harri; Illman, Mia; Laaksonen, Kristina; Jousmäki, Veikko; Forss, Nina
Contributor: University of Helsinki, Neurologian yksikkö
University of Helsinki, Clinicum
Date: 2018-10-01
Language: eng
Number of pages: 8
Belongs to series: NeuroImage
ISSN: 1053-8119
URI: http://hdl.handle.net/10138/304111
Abstract: Corticokinematic coherence (CKC) between limb kinematics and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. However, it is unclear whether strength of CKC is reproducible across measurement sessions. We thus examined reproducibility of CKC in a follow-up study. Thirteen healthy right-handed volunteers (7 females, 21.7 +/- 4.3 yrs) were measured using MEG in two separate sessions 12.6 +/- 1.3 months apart. The participant was seated and relaxed while his/her dominant or non-dominant index finger was continuously moved at 3 Hz (4 min for each hand) using a pneumatic movement actuator. Finger kinematics were recorded with a 3-axis accelerometer. Coherence was computed between finger acceleration and MEG signals. CKC strength was defined as the peak coherence value at 3 Hz form a single sensor among 40 pre-selected Rolandic gradiometers contralateral to the movement. Pneumatic movement actuator provided stable proprioceptive stimuli and significant CKC responses peaking at the contralateral Rolandic sensors. In the group level, CKC strength did not differ between the sessions in dominant (Day-1 0.40 +/- 0.19 vs. Day-2 0.41 +/- 0.17) or non-dominant (0.35 +/- 0.16 vs. 0.36 +/- 0.17) hand, nor between the hands. Intraclass-correlation coefficient (ICC) values indicated excellent inter-session reproducibility for CKC strength for both dominant (0.86) and non-dominant (0.97) hand. However, some participants showed pronounced inter-session variability in CKC strength, but only for the dominant hand. CKC is a promising tool to study proprioception in long-term longitudinal studies in the group level to follow, e.g., integrity of cortical proprioceptive processing with motor functions after stroke.
Subject: Proprioception
Movement evoked field
Kinematics
Magnetoencephalography
Somatosensory
Repeatability
MOTOR-CORTEX
PASSIVE FINGER
MEG
HANDEDNESS
REPRESENTATION
ASYMMETRY
MOVEMENTS
HUMANS
TASK
3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
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