Dopaminergic and serotonergic mechanisms in the modulation of pain : In vivo studies in human brain

Show full item record



Permalink

http://hdl.handle.net/10138/304181

Citation

Martikainen , I K , Hagelberg , N , Jääskelainen , S K , Hietala , J & Pertovaara , A 2018 , ' Dopaminergic and serotonergic mechanisms in the modulation of pain : In vivo studies in human brain ' , European Journal of Pharmacology , vol. 834 , pp. 337-345 . https://doi.org/10.1016/j.ejphar.2018.07.038

Title: Dopaminergic and serotonergic mechanisms in the modulation of pain : In vivo studies in human brain
Author: Martikainen, Ilkka K.; Hagelberg, Nora; Jääskelainen, Satu K.; Hietala, Jarmo; Pertovaara, Antti
Other contributor: University of Helsinki, Doctoral Programme Brain & Mind






Date: 2018-09-05
Language: eng
Number of pages: 9
Belongs to series: European Journal of Pharmacology
ISSN: 0014-2999
DOI: https://doi.org/10.1016/j.ejphar.2018.07.038
URI: http://hdl.handle.net/10138/304181
Abstract: Here we review the literature assessing the roles of the brain dopaminergic and serotonergic systems in the modulation of pain as revealed by in vivo human studies using positron emission tomography. In healthy subjects, dopamine D-2/D-3 receptor availability particularly in the striatum and serotonin 5-HT1A and 5-HT2A receptor availabilities in the cortex predict the subject's response to tonic experimental pain. High availability of dopamine D-2/D-3 or serotonin 5-HT2A receptors is associated with high pain intensity, whereas high availability of 5-HT1A receptors associates with low pain intensity. Chronic neuropathic pain is associated with high striatal dopamine D-2/D-3 receptor availability, for which low endogenous dopamine tone is a plausible explanation, although a compensatory increase in striatal dopamine D-2/D-3 receptor density may also contribute. In contrast, chronic musculoskeletal pain is associated with low baseline availability of striatal dopamine D-2/D-3 receptors. In healthy subjects, brain serotonin 5-HT1A as well as dopamine D-2/D-3 receptor availabilities associate with the subject's response criterion rather than the capacity to discriminate painful thermal stimuli suggesting that these neurotransmitter systems act mainly on non-sensory rather than sensory factors of thermally induced pain experience. Additionally, 5-HT1A receptor availability predicts the subject's discriminative ability but not response criterion for non-painful tactile test stimuli, while no such correlation is observed with dopamine D-2/D-3 receptors. These findings suggest that dopamine acting on striatal dopamine D-2/D-3 receptors and serotonin acting on cortical 5-HT1A and 5-HT2A receptors contribute to top-down pain regulation in humans.
Subject: Dopamine D-2/D-3 receptor
Serotonin 5-HT1A receptor
Serotonin 5-HT2A receptor
Positron emission tomography
Pain modulation
Psychophysics
BURNING MOUTH SYNDROME
TRANSCRANIAL MAGNETIC STIMULATION
POSITRON-EMISSION-TOMOGRAPHY
RESTLESS LEGS SYNDROME
D2 RECEPTOR-BINDING
MOTOR CORTEX STIMULATION
5-HT1A RECEPTORS
NEUROPATHIC HYPERSENSITIVITY
ANTINOCICEPTIVE ACTIONS
FIBROMYALGIA PATIENTS
3111 Biomedicine
317 Pharmacy
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0014299918304126_main.pdf 344.2Kb PDF View/Open
Dopaminergic_an ... studies_in_human_brain.pdf 559.1Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record