Multigenerational and Transgenerational Effects of Dioxins

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http://hdl.handle.net/10138/304245

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Viluksela , M & Pohjanvirta , R 2019 , ' Multigenerational and Transgenerational Effects of Dioxins ' , International Journal of Molecular Sciences , vol. 20 , no. 12 , 2947 . https://doi.org/10.3390/ijms20122947

Title: Multigenerational and Transgenerational Effects of Dioxins
Author: Viluksela, Matti; Pohjanvirta, Raimo
Other contributor: University of Helsinki, Raimo Pohjanvirta / Principal Investigator



Date: 2019-06-02
Language: eng
Number of pages: 22
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms20122947
URI: http://hdl.handle.net/10138/304245
Abstract: Dioxins are ubiquitous and persistent environmental contaminants whose background levels are still reason for concern. There is mounting evidence from both epidemiological and experimental studies that paternal exposure to the most potent congener of dioxins, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can lower the male/female ratio of offspring. Moreover, in laboratory rodents and zebrafish, TCDD exposure of parent animals has been reported to result in reduced reproductive performance along with other adverse effects in subsequent generations, foremost through the paternal but also via the maternal germline. These impacts have been accompanied by epigenetic alterations in placenta and/or sperm cells, including changes in methylation patterns of imprinted genes. Here, we review recent key studies in this field with an attempt to provide an up-to-date picture of the present state of knowledge to the reader. These studies provide biological plausibility for the potential of dioxin exposure at a critical time-window to induce epigenetic alterations across multiple generations and the significance of aryl hydrocarbon receptor (AHR) in mediating these effects. Currently available data do not allow to accurately estimate the human health implications of these findings, although epidemiological evidence on lowered male/female ratio suggests that this effect may take place at realistic human exposure levels.
Subject: 2
3
7
8-tetrachlorodibenzo-p-dioxin (TCDD)
dioxins
aryl hydrocarbon receptor
epigenetic modifications
transgenerational effects
gender ratio
preterm birth
paternal
maternal
ARYL-HYDROCARBON RECEPTOR
SPRAGUE-DAWLEY RATS
BREAST-CANCER CELLS
SEX-RATIO
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD
DNA METHYLATION
AH-RECEPTOR
OXIDATIVE STRESS
TRANSCRIPTIONAL SUPPRESSION
SUBCELLULAR-LOCALIZATION
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
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