CAIDE Dementia Risk Score, Alzheimer and cerebrovascular pathology : a population-based autopsy study

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http://hdl.handle.net/10138/304262

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Hooshmand , B , Polvikoski , T , Kivipelto , M , Myllykangas , L , Mäkelä , M , Tanskanen , M , Oinas , M , Paetau , A & Solomon , A 2018 , ' CAIDE Dementia Risk Score, Alzheimer and cerebrovascular pathology : a population-based autopsy study ' , Journal of internal medicine , vol. 283 , no. 6 , pp. 597-603 . https://doi.org/10.1111/joim.12736

Title: CAIDE Dementia Risk Score, Alzheimer and cerebrovascular pathology : a population-based autopsy study
Author: Hooshmand, B.; Polvikoski, T.; Kivipelto, M.; Myllykangas, L.; Mäkelä, M.; Tanskanen, M.; Oinas, Minna; Paetau, A.; Solomon, A.
Contributor: University of Helsinki, HUSLAB
University of Helsinki, HUSLAB
University of Helsinki, Department of Pathology
University of Helsinki, HUS Neurocenter
University of Helsinki, HUSLAB
Date: 2018-06
Language: eng
Number of pages: 7
Belongs to series: Journal of internal medicine
ISSN: 0954-6820
URI: http://hdl.handle.net/10138/304262
Abstract: Background. CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its longitudinal associations with Alzheimer or vascular neuropathology in the oldest old are not known. Aim. To explore the relationship between CAIDE Dementia Risk Score at baseline and neuritic plaques, neurofibrillary tangles, cerebral infarcts and cerebral amyloid angiopathy (CAA) after up to 10-year follow-up in the Vantaa 85+ population. Methods. Study population included 149 participants aged 85 years, without dementia at baseline, and with available clinical and autopsy data. Methenamine silver staining was used for beta-amyloid and modified Bielschowsky method for neurofibrillary tangles and neuritic plaques. Macroscopic infarcts were identified from cerebral hemispheres, brain-stem and cerebellum slices. Standardized methods were used to determine microscopic infarcts, CAA and alpha-synuclein pathologies. The CAIDE Dementia Risk Score was calculated based on scores for age, sex, BMI, total cholesterol, systolic blood pressure, physical activity and APOE epsilon 4 carrier status (range 0-18 points). Results. A CAIDE Dementia Risk Score above 11 points was associated with more cerebral infarctions up to 10 years later: OR (95% CI) was 2.10 (1.06-4.16). No associations were found with other neuropathologies. Conclusion. In a population of elderly aged 85 years, higher CAIDE Dementia Risk Score was associated with increased risk of cerebral infarcts.
Subject: Alzheimer pathology
CAIDE Dementia Risk Score
cerebrovascular pathology
dementia
elderly
LEWY BODIES DLB
APOLIPOPROTEIN-E
PREDICTION
DISEASE
NEUROPATHOLOGY
HOMOCYSTEINE
ASSOCIATIONS
AMYLOIDOSIS
CONSORTIUM
PREVENTION
3121 General medicine, internal medicine and other clinical medicine
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