Gestational diabetes with diabetes and prediabetes risks : a large observational study

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Shen , Y , Wang , P , Wang , L , Zhang , S , Liu , H , Li , W , Li , N , Li , W , Leng , J , Wang , J , Tian , H , Zhang , C , Tuomilehto , J , Yang , X , Yu , Z & Hu , G 2018 , ' Gestational diabetes with diabetes and prediabetes risks : a large observational study ' , European Journal of Endocrinology , vol. 179 , no. 1 , pp. 51-58 . https://doi.org/10.1530/EJE-18-0130

Title: Gestational diabetes with diabetes and prediabetes risks : a large observational study
Author: Shen, Yun; Wang, Peng; Wang, Leishen; Zhang, Shuang; Liu, Huikun; Li, Weiqin; Li, Nan; Li, Wei; Leng, Junhong; Wang, Jing; Tian, Huiguang; Zhang, Cuilin; Tuomilehto, Jaakko; Yang, Xilin; Yu, Zhijie; Hu, Gang
Contributor: University of Helsinki, Clinicum
Date: 2018-07
Language: eng
Number of pages: 8
Belongs to series: European Journal of Endocrinology
ISSN: 0804-4643
URI: http://hdl.handle.net/10138/304271
Abstract: Aims: To compare risks of early postpartum diabetes and prediabetes in Chinese women with and without gestational diabetes mellitus (GDM) during pregnancy. Subjects and methods: Tianjin GDM observational study included 1263 women with a history of GDM and 705 women without GDM who participated in the urban GDM universal screening survey by using World Health Organization's criteria. Postpartum diabetes and prediabetes were identified after a standard oral glucose tolerance test. Cox proportional hazards regression was used to assess risks of postpartum diabetes and prediabetes between women with and without GDM. Results: During a mean follow-up of 3.53 years postpartum, 90 incident cases of diabetes and 599 incident cases of prediabetes were identified. Multivariable-adjusted hazard ratios among women with prior GDM, compared with those without it, were 76.1 (95% Cl: 23.6-246) for diabetes and 25.4 (95% CI: 18.2-35.3) for prediabetes. When the mean follow-up extended to 4.40 years, 121 diabetes and 616 prediabetes cases were identified. Women with prior GDM had a 13.0-fold multivariable-adjusted risk (95% CI: 5.54-30.6) for diabetes and 2.15-fold risk (95% CI: 1.76-2.62) for prediabetes compared with women without GDM. The positive associations between GDM and the risks of postpartum diabetes and prediabetes were significant and persistent when stratified by younger and older than 30 years at delivery and normal weight and overweight participants. Conclusions: The present study indicated that women with prior GDM had significantly increased risks for postpartum diabetes and prediabetes, with the highest risk at the first 3-4 years after delivery, compared with those without GDM.
Subject: LONG-TERM RISK
CHINESE WOMEN
INCREASING PREVALENCE
METABOLIC SYNDROME
GLUCOSE-LEVELS
WEIGHT CHANGE
BIRTH COHORT
LATE-ONSET
MELLITUS
METAANALYSIS
3121 General medicine, internal medicine and other clinical medicine
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