Saliva and serum immune responses in apical periodontitis

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http://hdl.handle.net/10138/304455

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Pietiäinen , M , Liljestrand , J M , Akhi , R , Buhlin , K , Johansson , A , Paju , S , Salminen , A , Mäntylä , P , Sinisalo , J , Tjäderhane , L , Hörkkö , S & Pussinen , P 2019 , ' Saliva and serum immune responses in apical periodontitis ' , Journal of clinical medicine , vol. 8 , no. 6 , 889 . https://doi.org/10.3390/jcm8060889

Title: Saliva and serum immune responses in apical periodontitis
Author: Pietiäinen, Milla; Liljestrand, John M.; Akhi, Ramin; Buhlin, Kåre; Johansson, Anders; Paju, Susanna; Salminen, Aino; Mäntylä, Päivi; Sinisalo, Juha; Tjäderhane, Leo; Hörkkö, Sohvi; Pussinen, Pirkko
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, University of Eastern Finland
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
Date: 2019-06-21
Language: eng
Number of pages: 16
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
URI: http://hdl.handle.net/10138/304455
Abstract: Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01-8.33) and 4.91 (2.48-9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48-2.97)), serum IgG to bacterial antigens (4.66 (1.22-10.1)), and Gram-negative subgingival species (1.98 (1.16-3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05-21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis-a putative risk factor for systemic diseases.
Subject: 313 Dentistry
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
apical periodontitis
adaptive immunity
saliva
serum
antibody
PERSISTENT ENDODONTIC INFECTIONS
LOW-DENSITY-LIPOPROTEIN
CORONARY-HEART-DISEASE
PORPHYROMONAS-GINGIVALIS
PREVOTELLA-INTERMEDIA
ASSOCIATION
LESIONS
ANTIBODIES
PATHOGENS
HEALTH
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