Large-scale brain modes reorganize between infant sleep states and carry prognostic information for preterms

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dc.contributor University of Helsinki, Neuroscience Center en
dc.contributor University of Helsinki, Kliinisen neurofysiologian yksikkö en
dc.contributor.author Tokariev, Anton
dc.contributor.author Roberts, James A.
dc.contributor.author Zalesky, Andrew
dc.contributor.author Zhao, Xuelong
dc.contributor.author Vanhatalo, Sampsa
dc.contributor.author Breakspear, Michael
dc.contributor.author Cocchi, Luca
dc.date.accessioned 2019-08-14T08:47:01Z
dc.date.available 2019-08-14T08:47:01Z
dc.date.issued 2019-06-13
dc.identifier.citation Tokariev , A , Roberts , J A , Zalesky , A , Zhao , X , Vanhatalo , S , Breakspear , M & Cocchi , L 2019 , ' Large-scale brain modes reorganize between infant sleep states and carry prognostic information for preterms ' , Nature Communications , vol. 10 , 2619 . https://doi.org/10.1038/s41467-019-10467-8 en
dc.identifier.issn 2041-1723
dc.identifier.other PURE: 126119069
dc.identifier.other PURE UUID: 3adbb5ac-6622-47a0-b09c-cc4f742bf84a
dc.identifier.other WOS: 000471227300022
dc.identifier.other ORCID: /0000-0002-1202-9981/work/66035751
dc.identifier.uri http://hdl.handle.net/10138/304574
dc.description.abstract Sleep architecture carries vital information about brain health across the lifespan. In particular, the ability to express distinct vigilance states is a key physiological marker of neurological wellbeing in the newborn infant although systems-level mechanisms remain elusive. Here, we demonstrate that the transition from quiet to active sleep in newborn infants is marked by a substantial reorganization of large-scale cortical activity and functional brain networks. This reorganization is attenuated in preterm infants and predicts visual performance at two years. We find a striking match between these empirical effects and a computational model of large-scale brain states which uncovers fundamental biophysical mechanisms not evident from inspection of the data. Active sleep is defined by reduced energy in a uniform mode of neural activity and increased energy in two more complex anteroposterior modes. Preterm-born infants show a deficit in this sleep-related reorganization of modal energy that carries novel prognostic information. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights en
dc.subject FIELD-THEORY en
dc.subject RHYTHMS en
dc.subject EEG en
dc.subject CONNECTIVITY en
dc.subject EXPANSION en
dc.subject MEG en
dc.subject 3112 Neurosciences en
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology en
dc.title Large-scale brain modes reorganize between infant sleep states and carry prognostic information for preterms en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1038/s41467-019-10467-8
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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