Shetty , S A , Smidt , H & de Vos , W M 2019 , ' Reconstructing functional networks in the human intestinal tract using synthetic microbiomes : Systems Biology • Nanobiotechnology ' , Current Opinion in Biotechnology , vol. 58 , pp. 146-154 . https://doi.org/10.1016/j.copbio.2019.03.009
Title: | Reconstructing functional networks in the human intestinal tract using synthetic microbiomes : Systems Biology • Nanobiotechnology |
Author: | Shetty, Sudarshan A; Smidt, Hauke; de Vos, Willem M |
Contributor organization: | Director and Common Matters Willem Meindert Vos de / Principal Investigator de Vos & Salonen group HUMI - Human Microbiome Research Medicum |
Date: | 2019-08 |
Language: | eng |
Number of pages: | 9 |
Belongs to series: | Current Opinion in Biotechnology |
ISSN: | 0958-1669 |
DOI: | https://doi.org/10.1016/j.copbio.2019.03.009 |
URI: | http://hdl.handle.net/10138/304577 |
Abstract: | The human intestinal tract harbors one of the most densely populated and open microbial ecosystems. The application of multi-omics approaches has provided insight into a wide array of complex interactions between the various groups of mainly anaerobic colonic microbes as well as the host-microbe dialogue. Integration of multi-omits techniques in cultivation based experiments that vary in complexity from monocultures to synthetic microbial communities identified key metabolic players in the trophic interactions as well as their ecological dynamics. A synergy between these approaches will be of utmost importance to reconstruct the functional interaction networks at the ecosystem level within the human intestinal microbiome. The improved understanding of microbiome functioning at ecosystem level will further aid in developing better predictive models and design of effective microbiome modulation strategies for health benefits. |
Subject: |
AKKERMANSIA-MUCINIPHILA
ALTERED SCHAEDLER FLORA BACTERIA BACTEROIDES BUTYRATE FERMENTATION GEN. NOV. GUT MICROBIOTA OSCILLOSPIRA REFERENCE GENOMES 3111 Biomedicine |
Peer reviewed: | Yes |
Rights: | cc_by_nc_nd |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
Total number of downloads: Loading...
Files | Size | Format | View |
---|---|---|---|
1_s2.0_S0958166918302301_main.pdf | 761.1Kb |
View/ |