Reconstructing functional networks in the human intestinal tract using synthetic microbiomes

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Shetty , S A , Smidt , H & de Vos , W M 2019 , ' Reconstructing functional networks in the human intestinal tract using synthetic microbiomes : Systems Biology • Nanobiotechnology ' Current Opinion in Biotechnology , vol. 58 , pp. 146-154 . https://doi.org/10.1016/j.copbio.2019.03.009

Title: Reconstructing functional networks in the human intestinal tract using synthetic microbiomes;
Systems Biology • Nanobiotechnology
Author: Shetty, Sudarshan A; Smidt, Hauke; de Vos, Willem M
Contributor: University of Helsinki, Director and Common Matters
Date: 2019-04-06
Number of pages: 9
Belongs to series: Current Opinion in Biotechnology
ISSN: 0958-1669
URI: http://hdl.handle.net/10138/304577
Abstract: The human intestinal tract harbors one of the most densely populated and open microbial ecosystems. The application of multi-omics approaches has provided insight into a wide array of complex interactions between the various groups of mainly anaerobic colonic microbes as well as the host–microbe dialogue. Integration of multi-omics techniques in cultivation based experiments that vary in complexity from monocultures to synthetic microbial communities identified key metabolic players in the trophic interactions as well as their ecological dynamics. A synergy between these approaches will be of utmost importance to reconstruct the functional interaction networks at the ecosystem level within the human intestinal microbiome. The improved understanding of microbiome functioning at ecosystem level will further aid in developing better predictive models and design of effective microbiome modulation strategies for health benefits.
Subject: 3111 Biomedicine
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