Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Show full item record



Psychiat Genomics Consortium , Czamara , D , Eraslan , G , Page , C M , Lahti , J , Lahti-Pulkkinen , M , Hämäläinen , E , Kajantie , E , Laivuori , H , Villa , P M , Reynolds , R M , Nystad , W , Håberg , S E , London , S J , O'Donnell , K J , Garg , E , Meaney , M J , Entringer , S , Wadhwa , P D , Buss , C , Jones , M J , Lin , D T S , MacIsaac , J L , Kobor , M S , Koen , N , Zar , H J , Koenen , K C , Dalvie , S , Stein , D J , Kondofersky , I , Mueller , N S , Theis , F J , Raikkonen , K & Binder , E B 2019 , ' Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns ' , Nature Communications , vol. 10 , 2548 .

Title: Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Author: Psychiat Genomics Consortium; Czamara, Darina; Eraslan, Goekcen; Page, Christian M.; Lahti, Jari; Lahti-Pulkkinen, Marius; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Nystad, Wenche; Håberg, Siri E.; London, Stephanie J.; O'Donnell, Kieran J.; Garg, Elika; Meaney, Michael J.; Entringer, Sonja; Wadhwa, Pathik D.; Buss, Claudia; Jones, Meaghan J.; Lin, David T. S.; MacIsaac, Julie L.; Kobor, Michael S.; Koen, Nastassja; Zar, Heather J.; Koenen, Karestan C.; Dalvie, Shareefa; Stein, Dan J.; Kondofersky, Ivan; Mueller, Nikola S.; Theis, Fabian J.; Raikkonen, Katri; Binder, Elisabeth B.
Contributor organization: Department of Psychology and Logopedics
Helsinki Collegium for Advanced Studies
Faculty of Medicine
Developmental Psychology Research Group
Department of Diagnostics and Therapeutics
HUS Children and Adolescents
Lastentautien yksikkö
Children's Hospital
HUS Gynecology and Obstetrics
Institute for Molecular Medicine Finland
Pregnancy and Genes
Department of Medical and Clinical Genetics
Department of Obstetrics and Gynecology
Helsinki Institute of Life Science HiLIFE
Genomics of Neurological and Neuropsychiatric Disorders
Date: 2019-06-11
Language: eng
Number of pages: 18
Belongs to series: Nature Communications
ISSN: 2041-1723
Abstract: Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41467_019_10461_0.pdf 1.071Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record