Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

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http://hdl.handle.net/10138/304586

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Miroshnikova , Y A , Cohen , I , Ezhkova , E & Wickström , S A 2019 , ' Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis ' , Current Opinion in Genetics & Development , vol. 55 , pp. 46-51 . https://doi.org/10.1016/j.gde.2019.04.014

Title: Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
Author: Miroshnikova, Yekaterina A; Cohen, Idan; Ezhkova, Elena; Wickström, Sara A
Contributor: University of Helsinki, Helsinki Institute of Life Science HiLIFE
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
Date: 2019-04
Number of pages: 6
Belongs to series: Current Opinion in Genetics & Development
ISSN: 0959-437X
URI: http://hdl.handle.net/10138/304586
Abstract: The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.
Subject: 1184 Genetics, developmental biology, physiology
3111 Biomedicine
STEM-CELLS
P63
DIFFERENTIATION
COMPLEX
SKIN
PROLIFERATION
ORGANIZATION
ACTIVATION
ENHANCERS
ROLES
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