Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes

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dc.contributor University of Helsinki, Children's Hospital en
dc.contributor University of Helsinki, National Institute for Health and Welfare en
dc.contributor University of Helsinki, Children's Hospital en
dc.contributor.author Mäkinen, Marjaana
dc.contributor.author Löyttyniemi, Eliisa
dc.contributor.author Koskinen, Maarit
dc.contributor.author Vähä-Mäkilä, Mari
dc.contributor.author Siljander, Heli
dc.contributor.author Nurmio, Mirja
dc.contributor.author Mykkänen, Juha
dc.contributor.author Virtanen, Suvi M.
dc.contributor.author Simell, Olli
dc.contributor.author Hyöty, Heikki
dc.contributor.author Ilonen, Jorma
dc.contributor.author Knip, Mikael
dc.contributor.author Veijola, Riitta
dc.contributor.author Toppari, Jorma
dc.date.accessioned 2019-08-19T10:49:01Z
dc.date.available 2019-08-19T10:49:01Z
dc.date.issued 2019-06
dc.identifier.citation Mäkinen , M , Löyttyniemi , E , Koskinen , M , Vähä-Mäkilä , M , Siljander , H , Nurmio , M , Mykkänen , J , Virtanen , S M , Simell , O , Hyöty , H , Ilonen , J , Knip , M , Veijola , R & Toppari , J 2019 , ' Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes ' , Journal of Clinical Endocrinology and Metabolism , vol. 104 , no. 6 , pp. 2277-2285 . https://doi.org/10.1210/jc.2018-02094 en
dc.identifier.issn 0021-972X
dc.identifier.other PURE: 126210169
dc.identifier.other PURE UUID: 2e3c7e13-26f9-46e0-99f6-fd490cc795a6
dc.identifier.other WOS: 000471028400046
dc.identifier.uri http://hdl.handle.net/10138/304747
dc.description.abstract Vitamin D has several effects on the immune system that might be of relevance for the pathogenesis of type 1 diabetes (T1D).To evaluate whether umbilical cord serum concentrations of 25-hydroxy-vitamin D (25[OH]D) differ in children developing either islet autoimmunity (IA) or overt T1D during childhood and adolescence.Umbilical cord serum samples from 764 children born from 1994 to 2004 with HLA-DQB1 conferred risk for T1D participating in the Type 1 Diabetes Prediction and Prevention Study were analyzed for 25(OH)D using an enzyme immunoassay.DIPP clinics in Turku, Oulu, and Tampere University Hospitals, Finland.Two hundred fifty children who developed T1D diabetes at a median age of 6.7 years (interquartile range [IQR] 4.0 to 10.1 years) and 132 additional case children who developed IA, i.e., positivity for multiple islet autoantibodies. Cases were matched for date of birth, gender, and area of birth with 382 control children who remained autoantibody negative. The median duration of follow up was 9.8 years (IQR 5.7 to 13.1 years).The median 25(OH)D concentrations.The median 25(OH)D concentration in cord serum was low [31.1 nmol/L (IQR 24.0 to 41.8); 88% <50 nmol/L], but not statistically different between children who developed T1D or IA and their control groups (P = 0.70). The levels were associated mainly with geographical location, year and month of birth, age of the mother, and maternal intake of vitamin D during pregnancy.The 25(OH)D concentrations at birth are not associated with the development of T1D during childhood. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Journal of Clinical Endocrinology and Metabolism
dc.rights en
dc.subject 3111 Biomedicine en
dc.subject BLOOD VITAMIN-D en
dc.subject CHILDHOOD en
dc.subject PREGNANCY en
dc.subject AUTOIMMUNITY en
dc.subject ASSOCIATION en
dc.subject PREDICTION en
dc.title Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes en
dc.type Article
dc.description.version Peer reviewed
dc.description.version Non Peer reviewed
dc.identifier.doi https://doi.org/10.1210/jc.2018-02094
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.type.uri http://purl.org/eprint/status/NonPeerReviewed
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