Can Gut Microbiota Composition Predict Response to Dietary Treatments?

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Biesiekierski , J R , Jalanka , J & Staudacher , H M 2019 , ' Can Gut Microbiota Composition Predict Response to Dietary Treatments? ' , Nutrients , vol. 11 , no. 5 , 1134 . https://doi.org/10.3390/nu11051134

Title: Can Gut Microbiota Composition Predict Response to Dietary Treatments?
Author: Biesiekierski, Jessica R.; Jalanka, Jonna; Staudacher, Heidi M.
Other contributor: University of Helsinki, Immunobiology Research Program



Date: 2019-05
Language: eng
Number of pages: 15
Belongs to series: Nutrients
ISSN: 2072-6643
DOI: https://doi.org/10.3390/nu11051134
URI: http://hdl.handle.net/10138/304920
Abstract: Dietary intervention is a challenge in clinical practice because of inter-individual variability in clinical response. Gut microbiota is mechanistically relevant for a number of disease states and consequently has been incorporated as a key variable in personalised nutrition models within the research context. This paper aims to review the evidence related to the predictive capacity of baseline microbiota for clinical response to dietary intervention in two specific health conditions, namely, obesity and irritable bowel syndrome (IBS). Clinical trials and larger predictive modelling studies were identified and critically evaluated. The findings reveal inconsistent evidence to support baseline microbiota as an accurate predictor of weight loss or glycaemic response in obesity, or as a predictor of symptom improvement in irritable bowel syndrome, in dietary intervention trials. Despite advancement in quantification methodologies, research in this area remains challenging and larger scale studies are needed until personalised nutrition is realistically achievable and can be translated to clinical practice.
Subject: personalised nutrition
microbiota
dietary intervention
obesity
irritable bowel syndrome
gastrointestinal symptoms
IRRITABLE-BOWEL-SYNDROME
LOW FODMAP DIET
BODY-MASS INDEX
FECAL MICROBIOTA
WEIGHT-LOSS
GASTROINTESTINAL MICROBIOTA
INTESTINAL MICROBIOTA
METABOLIC SYNDROME
CLINICAL-RESPONSE
REDUCES SYMPTOMS
3143 Nutrition
3121 General medicine, internal medicine and other clinical medicine
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