Infant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood.

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Toffol , E , Rantalainen , V , Lahti-Pulkkinen , M , Girchenko , P , Lahti , J , Tuovinen , S , Lipsanen , J , Villa , P M , Laivuori , H , Hämäläinen , E , Kajantie , E & Räikkönen , K 2019 , ' Infant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood. ' , European Child & Adolescent Psychiatry , vol. 28 , no. 6 , pp. 847-859 . https://doi.org/10.1007/s00787-018-1243-8

Title: Infant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood.
Author: Toffol, Elena; Rantalainen, Ville; Lahti-Pulkkinen, Marius; Girchenko, Polina; Lahti, Jari; Tuovinen, Soile; Lipsanen, Jari; Villa, Pia M.; Laivuori, Hannele; Hämäläinen, Esa; Kajantie, Eero; Räikkönen, Katri
Contributor organization: Department of Psychology and Logopedics
University of Helsinki
Helsinki Collegium for Advanced Studies
HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
Pregnancy and Genes
Institute for Molecular Medicine Finland
Department of Medical and Clinical Genetics
HUSLAB
Department of Clinical Chemistry and Hematology
HUS Children and Adolescents
Lastentautien yksikkö
Children's Hospital
Developmental Psychology Research Group
Genomics of Neurological and Neuropsychiatric Disorders
Teachers' Academy
Date: 2019-06
Language: eng
Number of pages: 13
Belongs to series: European Child & Adolescent Psychiatry
ISSN: 1018-8827
DOI: https://doi.org/10.1007/s00787-018-1243-8
URI: http://hdl.handle.net/10138/304924
Abstract: Whether infant regulatory behavior problems already in the first month of life indicate an increased risk of childhood neurobehavioral problems, and whether maternal depression in the postpartum and early childhood underpins these associations remain unclear. Altogether, 2049-2364 mothers from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Neonatal Perception Inventory on regulatory behavior problems at the infant's age of 15.6 days (SD 3.2, range 1-30), the Infant Behavior Questionnaire-Revised on temperament at 6.5 months (SD 0.9, range 4.2-12.4), and the Ages and Stages Questionnaire-3 on developmental milestones and the Child Behavior Checklist on behavioral problems at 3.5 years (SD 0.7, range 1.9-6.0). Maternal depressive symptoms were measured by the Center for Epidemiological Studies Depression Scale (infancy follow-ups) and Beck Depression Inventory-II (childhood follow-up). Father-rated infant temperament and paternal depressive symptoms were also available (n = 1474). Higher levels of infant regulatory behavior problems predicted higher levels of mother- and father-rated negative affectivity temperament (0.13 SD units per SD unit, 95% confidence interval 0.09-0.17; and 0.09, 0.04-0.14, respectively), lower levels of mother-rated orienting/regulation temperament (- 0.09, - 0.13 to - 0.05) and problem-solving skills (- 0.12, - 0.21 to - 0.04), and higher levels of Externalizing (0.07, 0.03-0.11) and Total behavioral problems (0.07, 0.03-0.11). Regulatory behaviors partially mediated the effect of maternal depressive symptoms. Regulatory behavior problems already during the first month of life predict neurobehavioral outcomes, and partially mediate the effect of maternal depressive symptoms. Our study may inform design of interventions aimed at timely prevention in children at risk.
Subject: 3124 Neurology and psychiatry
515 Psychology
Regulatory behavior
Infant
Depressive symptoms
Temperament
Neurobehavioral outcomes
MATERNAL DEPRESSION
FEEDING PROBLEMS
CHILDREN BORN
AGE
TEMPERAMENT
DISORDERS
SYMPTOMS
VALIDITY
STRESS
RISK
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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