Fibroblast as a critical stromal cell type determining prognosis in prostate cancer

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Blom , S , Erickson , A , Östman , A , Rannikko , A , Mirtti , T , Kallioniemi , O & Pellinen , T 2019 , ' Fibroblast as a critical stromal cell type determining prognosis in prostate cancer ' , Prostate , vol. 79 , no. 13 , pp. 1505-1513 . https://doi.org/10.1002/pros.23867

Title: Fibroblast as a critical stromal cell type determining prognosis in prostate cancer
Author: Blom, Sami; Erickson, Andrew; Östman, Arne; Rannikko, Antti; Mirtti, Tuomas; Kallioniemi, Olli; Pellinen, Teijo
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, HUS Abdominal Center
University of Helsinki, Research Program in Systems Oncology
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-09
Language: eng
Number of pages: 9
Belongs to series: Prostate
ISSN: 0270-4137
URI: http://hdl.handle.net/10138/304930
Abstract: Background Tumor stroma associates with prostate cancer (PCa) progression, but its specific cellular composition and association to patient survival outcome have not been characterized. Methods We analyzed stromal composition in human PCa using multiplex immunohistochemistry and quantitative, high-resolution image analysis in two retrospective, formalin-fixed paraffin embedded observational clinical cohorts (Cohort I, n = 117; Cohort II, n = 340) using PCa-specific mortality as outcome measurement. Results A high proportion of fibroblasts associated with aggressive disease and castration-resistant prostate cancer (CRPC). In a multivariate analysis, increase in fibroblast proportion predicted poor cancer-specific outcome independently in the two clinical cohorts studied. Conclusions Fibroblasts were the most important cell type in determining prognosis in PCa and associated with CRPC. Thus, the stromal composition could be critically important in developing diagnostic and therapeutic approaches to aggressive prostate cancer.
Subject: castration-resistant prostate cancer
digital image analysis
multiplex tissue imaging
RECURRENCE-FREE SURVIVAL
REACTIVE STROMA
CARCINOMA
EXPRESSION
TUMORS
3126 Surgery, anesthesiology, intensive care, radiology
3122 Cancers
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