Longitudinal assessment of microbial dysbiosis, fecal unconjugated bile acid concentrations, and disease activity in dogs with steroid-responsive chronic inflammatory enteropathy

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Guard , B C , Honneffer , J B , Jergens , A E , Jonika , M M , Toresson , L , Lawrence , Y A , Webb , C B , Hill , S , Lidbury , J A , Steiner , J M & Suchodolski , J S 2019 , ' Longitudinal assessment of microbial dysbiosis, fecal unconjugated bile acid concentrations, and disease activity in dogs with steroid-responsive chronic inflammatory enteropathy ' , Journal of Veterinary Internal Medicine , vol. 33 , no. 3 , pp. 1295-1305 . https://doi.org/10.1111/jvim.15493

Title: Longitudinal assessment of microbial dysbiosis, fecal unconjugated bile acid concentrations, and disease activity in dogs with steroid-responsive chronic inflammatory enteropathy
Author: Guard, Blake C.; Honneffer, Julia B.; Jergens, Albert E.; Jonika, Michelle M.; Toresson, Linda; Lawrence, Yuri A.; Webb, Craig B.; Hill, Steve; Lidbury, Jonathan A.; Steiner, Joerg M.; Suchodolski, Jan S.
Other contributor: University of Helsinki, Equine and Small Animal Medicine

Date: 2019-05
Language: eng
Number of pages: 11
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
DOI: https://doi.org/10.1111/jvim.15493
URI: http://hdl.handle.net/10138/304942
Abstract: Abstract Background Mounting evidence from human studies suggests that bile acid dysmetabolism might play a role in various human chronic gastrointestinal diseases. It is unknown whether fecal bile acid dysmetabolism occurs in dogs with chronic inflammatory enteropathy (CE). Objective To assess microbial dysbiosis, fecal unconjugated bile acids (fUBA), and disease activity in dogs with steroid-responsive CE. Animals Twenty-four healthy control dogs and 23 dogs with steroid-responsive CE. Methods In this retrospective study, fUBA were measured and analyzed. Fecal microbiota were assessed using a dysbiosis index. The canine inflammatory bowel disease activity index was used to evaluate remission of clinical signs. This was a multi-institutional study where dogs with steroid-responsive CE were evaluated over time. Results The dysbiosis index was increased in dogs with CE (median, 2.5; range, ?6.2 to 6.5) at baseline compared with healthy dogs (median, ?4.5; range, ?6.5 to ?2.6; P?=?.002) but did not change in dogs with CE over time. Secondary fUBA were decreased in dogs with CE (median, 29%; range, 1%-99%) compared with healthy dogs (median, 88%; 4%-96%; P?=?.049). The percent of secondary fUBA in dogs with CE increased from baseline values (median, 28%; range, 1%-99%) after 2-3?months of treatment (median, 94%; range, 1%-99%; P?=?0.0183). Conclusions and Clinical Importance These findings suggest that corticosteroids regulate fecal bile acids in dogs with CE. Additionally, resolution of clinical activity index in dogs with therapeutically managed CE and bile acid dysmetabolism are likely correlated. However, subclinical disease (i.e., microbial dysbiosis) can persist in dogs with steroid-responsive CE.
Subject: DIAGNOSIS
MALABSORPTION
METABOLISM
QUANTITATION
SALTS
TRANSPORT
bile acid dysmetabolism
chenodeoxycholic acid
cholic acid
deoxycholic acid
inflammatory bowel disease
lithocholic acid
413 Veterinary science
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