Converting FENO by different flows to standard flow FENO

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Lassmann-Klee , P G , Lehtimäki , L , Lindholm , T , Malmberg , L P , Sovijärvi , A R A & Piirilä , P L 2019 , ' Converting F ENO by different flows to standard flow F ENO ' , Clinical Physiology and Functional Imaging , vol. 39 , no. 5 , pp. 315-321 .

Title: Converting FENO by different flows to standard flow FENO
Author: Lassmann-Klee, Paul G.; Lehtimäki, Lauri; Lindholm, Tuula; Malmberg, Leo Pekka; Sovijärvi, Anssi R. A.; Piirilä, Päivi Liisa
Contributor organization: Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
University of Helsinki
HUS Inflammation Center
Department of Dermatology, Allergology and Venereology
Date: 2019-09
Language: eng
Number of pages: 7
Belongs to series: Clinical Physiology and Functional Imaging
ISSN: 1475-0961
Abstract: In clinical practice, assessment of expiratory nitric oxide (F-ENO) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of F-ENO is standardized to exhaled flow level of 50 ml s(-1), since the expiratory flow rate affects the F-ENO results. To enable the comparison of F-ENO measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate F-ENO at the standard flow level, and secondly, validate it in five external populations. F-ENO measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 ml s(-1), after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma and alveolitis. F-ENO conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated FENO from 100 ml s(-1) and measured F-ENO at 50 mL s(-1): -0 center dot 28 ppb, -0 center dot 44 ppb and 0 center dot 27 ppb, respectively. In patients with COPD, asthma and alveolitis, the deviation was -1 center dot 16 ppb, -1 center dot 68 ppb and 1 center dot 47 ppb, respectively. We proposed a valid model to convert F-ENO in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases and found it suitable for converting F-ENO measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert F-ENO from different flows to the standard flow was established and validated.
Subject: adults
fractional exhaled nitric oxide (F-ENO())
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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