Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens

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Hassan , K A , Liu , Q , Elbourne , L D H , Ahmad , I , Sharples , D , Naidu , V , Chan , C L , Li , L , Harborne , S P D , Pokhrel , A , Postis , V L G , Goldman , A , Henderson , P J F & Paulsen , I T 2018 , ' Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens ' , Research in Microbiology , vol. 169 , no. 7-8 , pp. 450-454 . https://doi.org/10.1016/j.resmic.2018.01.001

Title: Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens
Author: Hassan, Karl A.; Liu, Qi; Elbourne, Liam D.H.; Ahmad, Irshad; Sharples, David; Naidu, Varsha; Chan, Chak Lam; Li, Liping; Harborne, Steven P.D.; Pokhrel, Alaska; Postis, Vincent L.G.; Goldman, Adrian; Henderson, Peter J.F.; Paulsen, Ian T.
Contributor organization: Molecular and Integrative Biosciences Research Programme
Biochemistry and Biotechnology
Biosciences
Date: 2018
Language: eng
Number of pages: 5
Belongs to series: Research in Microbiology
ISSN: 0923-2508
DOI: https://doi.org/10.1016/j.resmic.2018.01.001
URI: http://hdl.handle.net/10138/305092
Abstract: Abstract The proteobacterial antimicrobial compound efflux (PACE) family of transport proteins was only recently described. PACE family transport proteins can confer resistance to a range of biocides used as disinfectants and antiseptics, and are encoded by many important Gram-negative human pathogens. However, we are only just beginning to appreciate the range of functions and the mechanism(s) of transport operating in these proteins. Genes encoding PACE family proteins are typically conserved in the core genomes of bacterial species rather than on recently acquired mobile genetic elements, suggesting that they confer important core functions in addition to biocide resistance. Three-dimensional structural information is not yet available for PACE family proteins. However, PACE proteins have several very highly conserved amino acid sequence motifs that are likely to be important for substrate transport. PACE proteins also display strong amino acid sequence conservation between their N- and C-terminal halves, suggesting that they evolved by duplication of an ancestral protein comprised of two transmembrane helices. In light of their drug resistance functions in Gram-negative pathogens, PACE proteins should be the subject of detailed future investigation.
Subject: Antimicrobial resistance
Bacterial transmembrane pair domain
DATABASE
ESCHERICHIA-COLI
EXPRESSION
Efflux
Gram-negative pathogen
Membrane transport
NORM
PACE
PROTEIN
RESISTANCE
TRANSPORTERS
1183 Plant biology, microbiology, virology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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