Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in updates healthy dogs

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Höglund , K , Häggström , J , Hanås , S , Merveille , A -C , Gouni , V , Wiberg , M , Willesen , J L , Mc Entee , K , Sorensen , L M , Tiret , L , Seppälä , E H , Lohi , H , Chetboul , V , Fredholm , M , Lequarre , A -S & Ljungvall , I 2018 , ' Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in updates healthy dogs ' , Journal of Veterinary Cardiology , vol. 20 , no. 4 , pp. 244-253 . https://doi.org/10.1016/j.jvc.2018.05.002

Title: Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in updates healthy dogs
Author: Höglund, K.; Häggström, J.; Hanås, S.; Merveille, A. -C.; Gouni, V.; Wiberg, M.; Willesen, J. Lundgren; Mc Entee, K.; Sorensen, L. Mejer; Tiret, L.; Seppälä, E. H.; Lohi, H.; Chetboul, V.; Fredholm, M.; Lequarre, A. -S.; Ljungvall, I.
Contributor organization: Doctoral Programme in Clinical Veterinary Medicine
Maria Wiberg / Principal Investigator
Equine and Small Animal Medicine
Departments of Faculty of Veterinary Medicine
University of Helsinki
Research Programs Unit
Research Programme for Molecular Neurology
Doctoral Programme in Integrative Life Science
Hannes Tapani Lohi / Principal Investigator
Date: 2018-08
Language: eng
Number of pages: 10
Belongs to series: Journal of Veterinary Cardiology
ISSN: 1760-2734
DOI: https://doi.org/10.1016/j.jvc.2018.05.002
URI: http://hdl.handle.net/10138/305125
Abstract: Introduction: Serotonin (5-hydroxytryptamine [5-HT]) has several biological functions. In different species, excessive 5-HT has been linked to valvular lesions, similar to those seen in dogs with myxomatous mitral valve disease. Previous studies suggest higher 5-HT in healthy Cavalier King Charles Spaniels (CKCSs), a breed highly affected by myxomatous mitral valve disease, compared to other breeds. Objective: To investigate potential interbreed variation in serum 5-HT in healthy dogs. Animals: 483 healthy dogs of nine breeds aged 1-7 years. Methods: Dogs were examined at five European centers. Absence of cardiovascular, organ-related, or systemic diseases was ensured by thorough clinical investigations including echocardiography. Serum was frozen and later analyzed by enzyme-linked immunosorbent assay (ELISA). Results: Median 5-HT concentration was 252.5 (interquartile range = 145.5-390.6) ng/mL. Overall breed difference was found (p Conclusions: Interbreed variation in serum 5-HT concentration was found in healthy dogs aged 1-7 years. These differences should be taken into account when designing clinical studies. (C) 2018 Elsevier B.V. All rights reserved.
Subject: Breed difference
Biomarker
Canine
Heart valve
5-HT
MITRAL-VALVE DISEASE
KING CHARLES SPANIELS
PLATELET SEROTONIN
PERIPHERAL SEROTONIN
CARDIAC-FUNCTION
HEART-DISEASE
PLASMA
CANINE
EXPRESSION
BREED
413 Veterinary science
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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