Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in updates healthy dogs

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http://hdl.handle.net/10138/305125

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Höglund , K , Häggström , J , Hanås , S , Merveille , A -C , Gouni , V , Wiberg , M , Willesen , J L , Mc Entee , K , Sorensen , L M , Tiret , L , Seppälä , E H , Lohi , H , Chetboul , V , Fredholm , M , Lequarre , A -S & Ljungvall , I 2018 , ' Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in updates healthy dogs ' , Journal of Veterinary Cardiology , vol. 20 , no. 4 , pp. 244-253 . https://doi.org/10.1016/j.jvc.2018.05.002

Title: Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in updates healthy dogs
Author: Höglund, K.; Häggström, J.; Hanås, S.; Merveille, A. -C.; Gouni, V.; Wiberg, M.; Willesen, J. Lundgren; Mc Entee, K.; Sorensen, L. Mejer; Tiret, L.; Seppälä, E. H.; Lohi, H.; Chetboul, V.; Fredholm, M.; Lequarre, A. -S.; Ljungvall, I.
Contributor: University of Helsinki, Doctoral Programme in Clinical Veterinary Medicine
University of Helsinki, Research Programs Unit
University of Helsinki, Doctoral Programme in Clinical Veterinary Medicine
Date: 2018-08
Language: eng
Number of pages: 10
Belongs to series: Journal of Veterinary Cardiology
ISSN: 1760-2734
URI: http://hdl.handle.net/10138/305125
Abstract: Introduction: Serotonin (5-hydroxytryptamine [5-HT]) has several biological functions. In different species, excessive 5-HT has been linked to valvular lesions, similar to those seen in dogs with myxomatous mitral valve disease. Previous studies suggest higher 5-HT in healthy Cavalier King Charles Spaniels (CKCSs), a breed highly affected by myxomatous mitral valve disease, compared to other breeds. Objective: To investigate potential interbreed variation in serum 5-HT in healthy dogs. Animals: 483 healthy dogs of nine breeds aged 1-7 years. Methods: Dogs were examined at five European centers. Absence of cardiovascular, organ-related, or systemic diseases was ensured by thorough clinical investigations including echocardiography. Serum was frozen and later analyzed by enzyme-linked immunosorbent assay (ELISA). Results: Median 5-HT concentration was 252.5 (interquartile range = 145.5-390.6) ng/mL. Overall breed difference was found (p Conclusions: Interbreed variation in serum 5-HT concentration was found in healthy dogs aged 1-7 years. These differences should be taken into account when designing clinical studies. (C) 2018 Elsevier B.V. All rights reserved.
Subject: Breed difference
Biomarker
Canine
Heart valve
5-HT
MITRAL-VALVE DISEASE
KING CHARLES SPANIELS
PLATELET SEROTONIN
PERIPHERAL SEROTONIN
CARDIAC-FUNCTION
HEART-DISEASE
PLASMA
CANINE
EXPRESSION
BREED
413 Veterinary science
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