Distribution of lymph node metastases in esophageal carcinoma [TIGER study] : study protocol of a multinational observational study

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Hagens , E R C , Henegouwen , M I V B , van Sandick , J W , Cuesta , M A , van der Peet , D L , Heisterkamp , J , Nieuwenhuijzen , G A P , Rosman , C , Scheepers , J J G , Sosef , M N , van Hillegersberg , R , Lagarde , S M , Nilsson , M , Räsänen , J , Nafteux , P , Pattyn , P , Hoelscher , A H , Schroeder , W , Schneider , P M , Mariette , C , Castoro , C , Bonavina , L , Rosati , R , de Manzoni , G , Mattioli , S , Roig Garcia , J , Pera , M , Griffin , M , Wilkerson , P , Chaudry , M A , Sgromo , B , Tucker , O , Cheong , E , Moorthy , K , Walsh , T N , Reynolds , J , Tachimori , Y , Inoue , H , Matsubara , H , Kosugi , S , Chen , H , Law , S Y K , Pramesh , C S , Puntambekar , S P , Murthy , S , Linden , P , Hofstetter , W L , Kuppusamy , M K , Shen , K R , Darling , G E , Sabino , F D , Grimminger , P P , Meijer , S L , Bergman , J J G H M , Hulshof , M C C M , van Laarhoven , H W M , Mearadji , B , Bennink , R J , Annema , J T , Dijkgraaf , M G W & Gisbertz , S S 2019 , ' Distribution of lymph node metastases in esophageal carcinoma [TIGER study] : study protocol of a multinational observational study ' , BMC Cancer , vol. 19 , 662 . https://doi.org/10.1186/s12885-019-5761-7

Title: Distribution of lymph node metastases in esophageal carcinoma [TIGER study] : study protocol of a multinational observational study
Author: Hagens, Eliza R. C.; Henegouwen, Mark I. van Berge; van Sandick, Johanna W.; Cuesta, Miguel A.; van der Peet, Donald L.; Heisterkamp, Joos; Nieuwenhuijzen, Grard A. P.; Rosman, Camiel; Scheepers, Joris J. G.; Sosef, Meindert N.; van Hillegersberg, Richard; Lagarde, Sjoerd M.; Nilsson, Magnus; Räsänen, Jari; Nafteux, Philippe; Pattyn, Piet; Hoelscher, Arnulf H.; Schroeder, Wolfgang; Schneider, Paul M.; Mariette, Christophe; Castoro, Carlo; Bonavina, Luigi; Rosati, Riccardo; de Manzoni, Giovanni; Mattioli, Sandro; Roig Garcia, Josep; Pera, Manuel; Griffin, Michael; Wilkerson, Paul; Chaudry, M. Asif; Sgromo, Bruno; Tucker, Olga; Cheong, Edward; Moorthy, Krishna; Walsh, Thomas N.; Reynolds, John; Tachimori, Yuji; Inoue, Haruhiro; Matsubara, Hisahiro; Kosugi, Shin-ichi; Chen, Haiquan; Law, Simon Y. K.; Pramesh, C. S.; Puntambekar, Shailesh P.; Murthy, Sudish; Linden, Philip; Hofstetter, Wayne L.; Kuppusamy, Madhan K.; Shen, K. Robert; Darling, Gail E.; Sabino, Flavio D.; Grimminger, Peter P.; Meijer, Sybren L.; Bergman, Jacques J. G. H. M.; Hulshof, Maarten C. C. M.; van Laarhoven, Hanneke W. M.; Mearadji, Banafsche; Bennink, Roel J.; Annema, Jouke T.; Dijkgraaf, Marcel G. W.; Gisbertz, Suzanne S.
Contributor: University of Helsinki, III kirurgian klinikka
Date: 2019-07-04
Language: eng
Number of pages: 8
Belongs to series: BMC Cancer
ISSN: 1471-2407
URI: http://hdl.handle.net/10138/305141
Abstract: BackgroundAn important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients.MethodsThe TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival.DiscussionThe TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics.Trial registrationNCT03222895, date of registration: July 19th, 2017.
Subject: Esophageal cancer
Lymph node metastases
Lymphadenectomy
Esophagectomy
SQUAMOUS-CELL
CANCER
ADENOCARCINOMA
PATTERN
SPREAD
LYMPHADENECTOMY
DISSECTION
IMPACT
3122 Cancers
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