A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

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dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor.author Deelen, Joris
dc.contributor.author Kettunen, Johannes
dc.contributor.author Fischer, Krista
dc.contributor.author van der Spek, Ashley
dc.contributor.author Trompet, Stella
dc.contributor.author Kastenmueller, Gabi
dc.contributor.author Boyd, Andy
dc.contributor.author Zierer, Jonas
dc.contributor.author van den Akker, Erik B.
dc.contributor.author Ala-Korpela, Mika
dc.contributor.author Amin, Najaf
dc.contributor.author Demirkan, Ayse
dc.contributor.author Ghanbari, Mohsen
dc.contributor.author van Heemst, Diana
dc.contributor.author Ikram, M. Arfan
dc.contributor.author van Klinken, Jan Bert
dc.contributor.author Mooijaart, Simon P.
dc.contributor.author Peters, Annette
dc.contributor.author Salomaa, Veikko
dc.contributor.author Sattar, Naveed
dc.contributor.author Spector, Tim D.
dc.contributor.author Tiemeier, Henning
dc.contributor.author Verhoeven, Aswin
dc.contributor.author Waldenberger, Melanie
dc.contributor.author Wuertz, Peter
dc.contributor.author Smith, George Davey
dc.contributor.author Metspalu, Andres
dc.contributor.author Perola, Markus
dc.contributor.author Menni, Cristina
dc.contributor.author Geleijnse, Johanna M.
dc.contributor.author Drenos, Fotios
dc.contributor.author Beekman, Marian
dc.contributor.author Jukema, J. Wouter
dc.contributor.author van Duijn, Cornelia M.
dc.contributor.author Slagboom, P. Eline
dc.date.accessioned 2019-09-05T11:56:01Z
dc.date.available 2019-09-05T11:56:01Z
dc.date.issued 2019-08-20
dc.identifier.citation Deelen , J , Kettunen , J , Fischer , K , van der Spek , A , Trompet , S , Kastenmueller , G , Boyd , A , Zierer , J , van den Akker , E B , Ala-Korpela , M , Amin , N , Demirkan , A , Ghanbari , M , van Heemst , D , Ikram , M A , van Klinken , J B , Mooijaart , S P , Peters , A , Salomaa , V , Sattar , N , Spector , T D , Tiemeier , H , Verhoeven , A , Waldenberger , M , Wuertz , P , Smith , G D , Metspalu , A , Perola , M , Menni , C , Geleijnse , J M , Drenos , F , Beekman , M , Jukema , J W , van Duijn , C M & Slagboom , P E 2019 , ' A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals ' , Nature Communications , vol. 10 , 3346 . https://doi.org/10.1038/s41467-019-11311-9 en
dc.identifier.issn 2041-1723
dc.identifier.other PURE: 126524285
dc.identifier.other PURE UUID: 08915e4c-2628-49f1-b13e-1f1f4a481cdb
dc.identifier.other WOS: 000481748600001
dc.identifier.uri http://hdl.handle.net/10138/305241
dc.description.abstract Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic predictors of long-term mortality in the circulation of 44,168 individuals (age at baseline 18-109), of whom 5512 died during follow-up. We apply a stepwise (forward-backward) procedure based on meta-analysis results and identify 14 circulating biomarkers independently associating with all-cause mortality. Overall, these associations are similar in men and women and across different age strata. We subsequently show that the prediction accuracy of 5- and 10-year mortality based on a model containing the identified biomarkers and sex (C-statistic = 0.837 and 0.830, respectively) is better than that of a model containing conventional risk factors for mortality (C-statistic = 0.772 and 0.790, respectively). The use of the identified metabolic profile as a predictor of mortality or surrogate endpoint in clinical studies needs further investigation. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights en
dc.subject AMINO-ACIDS en
dc.subject ASSOCIATION en
dc.subject HYPERGLYCEMIA en
dc.subject EPIDEMIOLOGY en
dc.subject 3111 Biomedicine en
dc.title A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1038/s41467-019-11311-9
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion

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