Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop

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Kuony , A , Ikkala , K , Kalha , S , Magalhaes , A C , Pirttiniemi , A & Michon , F 2019 , ' Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop ' , Development , vol. 146 , no. 14 , 176693 . https://doi.org/10.1242/dev.176693

Title: Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop
Author: Kuony, Alison; Ikkala, Kaisa; Kalha, Solja; Magalhaes, Ana Cathia; Pirttiniemi, Anniina; Michon, Frederic
Other contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Doctoral Programme in Integrative Life Science
University of Helsinki, Institute of Biotechnology
University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, Development and Physiology of the Eye





Date: 2019-07
Language: eng
Number of pages: 11
Belongs to series: Development
ISSN: 0950-1991
DOI: https://doi.org/10.1242/dev.176693
URI: http://hdl.handle.net/10138/305337
Abstract: A lack of ectodysplasin-A (Eda) signaling leads to dry eye symptoms, which have so far only been associated with altered Meibomian glands. Here, we used loss-of-function (Eda(-/-)) mutant mice to unravel the impact of Eda signaling on lacrimal gland formation, maturation and subsequent physiological function. Our study demonstrates that Eda activity is dispensable during lacrimal gland embryonic development. However, using a transcriptomic approach, we show that the Eda pathway is necessary for proper cell terminal differentiation in lacrimal gland epithelium and correlated with modified expression of secreted factors commonly found in the tear film. Finally, we discovered that lacrimal glands present a bilateral reduction of Eda signaling activity in response to unilateral comeal injury. This observation hints towards a role for the Eda pathway in controlling the switch from basal to reflex tears, to support corneal wound healing. Collectively, our data suggest a crucial implication of Eda signaling in the comea-lacrimal gland feedback loop, both in physiological and pathophysiological conditions. Our findings demonstrate that Eda downstream targets could help alleviate dry eye symptoms.
Subject: Ectodysplasin
Lacrimal gland
Tear film
Cornea
Wound healing
EPITHELIAL BARRIER FUNCTION
DRY EYE
BRANCHING-MORPHOGENESIS
GROWTH-FACTOR
TEAR FILM
MOUSE
EDAR
EXPRESSION
HAIR
GENE
1184 Genetics, developmental biology, physiology
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