Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure

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dc.contributor.author HOT-ICU Investigators
dc.contributor.author Schjorring, Olav L.
dc.contributor.author Perner, Anders
dc.contributor.author Wetterslev, Jorn
dc.contributor.author Lange, Theis
dc.contributor.author Keus, Frederik
dc.contributor.author Laake, Jon H.
dc.contributor.author Okkonen, Marjatta
dc.contributor.author Siegemund, Martin
dc.contributor.author Morgan, Matthew
dc.contributor.author Thormar, Katrin M.
dc.contributor.author Rasmussen, Bodil S.
dc.date.accessioned 2019-09-10T06:47:01Z
dc.date.available 2019-09-10T06:47:01Z
dc.date.issued 2019-08
dc.identifier.citation HOT-ICU Investigators , Schjorring , O L , Perner , A , Wetterslev , J , Lange , T , Keus , F , Laake , J H , Okkonen , M , Siegemund , M , Morgan , M , Thormar , K M & Rasmussen , B S 2019 , ' Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure ' , Acta Anaesthesiologica Scandinavica , vol. 63 , no. 7 , pp. 956-965 . https://doi.org/10.1111/aas.13356
dc.identifier.other PURE: 126663904
dc.identifier.other PURE UUID: 7adb2382-2a9c-49fc-9343-c4234b25f523
dc.identifier.other WOS: 000473992700016
dc.identifier.uri http://hdl.handle.net/10138/305344
dc.description.abstract Background Acutely ill adults with hypoxaemic respiratory failure are at risk of life-threatening hypoxia, and thus oxygen is often administered liberally. Excessive oxygen use may, however, increase the number of serious adverse events, including death. Establishing the optimal oxygenation level is important as existing evidence is of low quality. We hypothesise that targeting an arterial partial pressure of oxygen (PaO2) of 8 kPa is superior to targeting a PaO2 of 12 kPa in adult intensive care unit (ICU) patients with acute hypoxaemic respiratory failure. Methods The Handling Oxygenation Targets in the ICU (HOT-ICU) trial is an outcome assessment blinded, multicentre, randomised, parallel-group trial targeting PaO2 in acutely ill adults with hypoxaemic respiratory failure within 12 hours after ICU admission. Patients are randomised 1:1 to one of the two PaO2 targets throughout ICU stay until a maximum of 90 days. The primary outcome is 90-day mortality. Secondary outcomes are serious adverse events in the ICU, days alive without organ support and days alive out of hospital in the 90-day period; mortality, health-related quality-of-life at 1-year follow-up as well as 1-year cognitive and pulmonary function in a subgroup; and an overall health economic analysis. To detect or reject a 20% relative risk reduction, we aim to include 2928 patients. An interim analysis is planned after 90-day follow-up of 1464 patients. Conclusion The HOT-ICU trial will test the hypothesis that a lower oxygenation target reduces 90-day mortality compared with a higher oxygenation target in adult ICU patients with acute hypoxaemic respiratory failure. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Acta Anaesthesiologica Scandinavica
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject critical illness
dc.subject hyperoxia
dc.subject hypoxia
dc.subject intensive care units
dc.subject mortality
dc.subject oxygen inhalation therapy
dc.subject pragmatic clinical trial
dc.subject randomised controlled trial
dc.subject respiratory insufficiency
dc.subject MECHANICALLY VENTILATED PATIENTS
dc.subject CRITICALLY-ILL PATIENTS
dc.subject ARTERIAL HYPEROXIA
dc.subject PRACTICE GUIDELINE
dc.subject CRITICAL ILLNESS
dc.subject OUTCOMES
dc.subject MORTALITY
dc.subject THERAPY
dc.subject SEPSIS
dc.subject ATELECTASIS
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.title Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure en
dc.type Review Article
dc.contributor.organization HUS Perioperative, Intensive Care and Pain Medicine
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Anestesiologian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/aas.13356
dc.relation.issn 0001-5172
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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