Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer

Show full item record

Permalink

http://hdl.handle.net/10138/305361

Citation

Lanki , M , Seppänen , H , Mustonen , H , Hagström , J & Haglund , C 2019 , ' Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer ' , PLoS One , vol. 14 , no. 7 , 0219245 . https://doi.org/10.1371/journal.pone.0219245

Title: Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer
Author: Lanki, Mira; Seppänen, Hanna; Mustonen, Harri; Hagström, Jaana; Haglund, Caj
Contributor: University of Helsinki, Department of Surgery
University of Helsinki, CAN-PRO - Translational Cancer Medicine Program
University of Helsinki, HUS Abdominal Center
University of Helsinki, University Management
University of Helsinki, HUS Abdominal Center
Date: 2019-07-17
Number of pages: 11
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/305361
Abstract: Background The link between inflammation and carcinogenesis is indisputable. In trying to understand key factors at play, cancer research has developed an interest in the toll-like receptors (TLRs), which have shown signs of having prognostic value in various adenocarcinomas. We began investigating the expression of toll-like receptors 1, 3, 5, 7, and 9 to evaluate their prognostic value of patients with pancreatic ductal adenocarcinoma (PDAC). Methods We collected tumor biopsies from 154 stage I-III PDAC patients surgically treated at Helsinki University Hospital between 2002 and 2011, excluding patients undergoing neoadjuvant therapy. We used tissue microarray slides and immunohistochemistry to assess expression of TLRs 1, 3, 5, 7, and 9 in PDAC tissue. Immunopositivity scores and clinicopathological characteristics were subjected to Fisher's exact test or the linear-by-linear association test. For the survival analysis, we applied the Kaplan-Meier method and log-rank test, and the Cox regression proportional hazard model served for univariate and multivariate analyses. Results Strong TLR1 expression was observable in 60 (39%), strong TLR3 in 48 (31%), strong TLR5 in 58 (38%), strong TLR7 in 14 (9%), and strong TLR9 in 22 (14%) patients. The multivariate analysis showed strong TLR1 expression to associate with better survival than moderate, low, or negative expression (HR = 0.68; 95% CI 0.47-0.99; p = 0.044). Additionally, those few patients with tumors negative for TLR1, TLR3, TLR7, or TLR9 fared poorly (HR = 2.41; 95% CI 1.31-4.43; p = 0.005; n = 13). Conclusion Strong TLR1 expression suggested better prognosis in PDAC patients, whereas negative expression of TLR1, TLR3, TLR7, or TLR9 was a sign of poor prognosis.
Subject: CELL-PROLIFERATION
EXPRESSION
CHEMORESISTANCE
PROGRESSION
INVASION
TLR9
3111 Biomedicine
3122 Cancers
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
journal.pone.0219245.pdf 1.178Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record