Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer

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http://hdl.handle.net/10138/305361

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Lanki , M , Seppänen , H , Mustonen , H , Hagström , J & Haglund , C 2019 , ' Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer ' , PLoS One , vol. 14 , no. 7 , 0219245 . https://doi.org/10.1371/journal.pone.0219245

Titel: Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer
Författare: Lanki, Mira; Seppänen, Hanna; Mustonen, Harri; Hagström, Jaana; Haglund, Caj
Upphovmannens organisation: Department of Surgery
University of Helsinki
HUS Abdominal Center
CAN-PRO - Translational Cancer Medicine Program
Research Programs Unit
II kirurgian klinikka
University Management
Clinicum
Medicum
Department of Pathology
HUS Helsinki and Uusimaa Hospital District
HUSLAB
Datum: 2019-07-17
Språk: eng
Sidantal: 11
Tillhör serie: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0219245
Permanenta länken (URI): http://hdl.handle.net/10138/305361
Abstrakt: Background The link between inflammation and carcinogenesis is indisputable. In trying to understand key factors at play, cancer research has developed an interest in the toll-like receptors (TLRs), which have shown signs of having prognostic value in various adenocarcinomas. We began investigating the expression of toll-like receptors 1, 3, 5, 7, and 9 to evaluate their prognostic value of patients with pancreatic ductal adenocarcinoma (PDAC). Methods We collected tumor biopsies from 154 stage I-III PDAC patients surgically treated at Helsinki University Hospital between 2002 and 2011, excluding patients undergoing neoadjuvant therapy. We used tissue microarray slides and immunohistochemistry to assess expression of TLRs 1, 3, 5, 7, and 9 in PDAC tissue. Immunopositivity scores and clinicopathological characteristics were subjected to Fisher's exact test or the linear-by-linear association test. For the survival analysis, we applied the Kaplan-Meier method and log-rank test, and the Cox regression proportional hazard model served for univariate and multivariate analyses. Results Strong TLR1 expression was observable in 60 (39%), strong TLR3 in 48 (31%), strong TLR5 in 58 (38%), strong TLR7 in 14 (9%), and strong TLR9 in 22 (14%) patients. The multivariate analysis showed strong TLR1 expression to associate with better survival than moderate, low, or negative expression (HR = 0.68; 95% CI 0.47-0.99; p = 0.044). Additionally, those few patients with tumors negative for TLR1, TLR3, TLR7, or TLR9 fared poorly (HR = 2.41; 95% CI 1.31-4.43; p = 0.005; n = 13). Conclusion Strong TLR1 expression suggested better prognosis in PDAC patients, whereas negative expression of TLR1, TLR3, TLR7, or TLR9 was a sign of poor prognosis.
Subject: CELL-PROLIFERATION
EXPRESSION
CHEMORESISTANCE
PROGRESSION
INVASION
TLR9
3111 Biomedicine
3122 Cancers
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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