Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer

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dc.contributor.author Lanki, Mira
dc.contributor.author Seppänen, Hanna
dc.contributor.author Mustonen, Harri
dc.contributor.author Hagström, Jaana
dc.contributor.author Haglund, Caj
dc.date.accessioned 2019-09-10T12:51:01Z
dc.date.available 2019-09-10T12:51:01Z
dc.date.issued 2019-07-17
dc.identifier.citation Lanki , M , Seppänen , H , Mustonen , H , Hagström , J & Haglund , C 2019 , ' Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer ' , PLoS One , vol. 14 , no. 7 , 0219245 . https://doi.org/10.1371/journal.pone.0219245
dc.identifier.other PURE: 126673786
dc.identifier.other PURE UUID: b107e208-4299-4147-83a4-4720243232eb
dc.identifier.other WOS: 000482331900026
dc.identifier.other ORCID: /0000-0001-6079-7881/work/61592360
dc.identifier.other ORCID: /0000-0001-5632-6796/work/61593277
dc.identifier.uri http://hdl.handle.net/10138/305361
dc.description.abstract Background The link between inflammation and carcinogenesis is indisputable. In trying to understand key factors at play, cancer research has developed an interest in the toll-like receptors (TLRs), which have shown signs of having prognostic value in various adenocarcinomas. We began investigating the expression of toll-like receptors 1, 3, 5, 7, and 9 to evaluate their prognostic value of patients with pancreatic ductal adenocarcinoma (PDAC). Methods We collected tumor biopsies from 154 stage I-III PDAC patients surgically treated at Helsinki University Hospital between 2002 and 2011, excluding patients undergoing neoadjuvant therapy. We used tissue microarray slides and immunohistochemistry to assess expression of TLRs 1, 3, 5, 7, and 9 in PDAC tissue. Immunopositivity scores and clinicopathological characteristics were subjected to Fisher's exact test or the linear-by-linear association test. For the survival analysis, we applied the Kaplan-Meier method and log-rank test, and the Cox regression proportional hazard model served for univariate and multivariate analyses. Results Strong TLR1 expression was observable in 60 (39%), strong TLR3 in 48 (31%), strong TLR5 in 58 (38%), strong TLR7 in 14 (9%), and strong TLR9 in 22 (14%) patients. The multivariate analysis showed strong TLR1 expression to associate with better survival than moderate, low, or negative expression (HR = 0.68; 95% CI 0.47-0.99; p = 0.044). Additionally, those few patients with tumors negative for TLR1, TLR3, TLR7, or TLR9 fared poorly (HR = 2.41; 95% CI 1.31-4.43; p = 0.005; n = 13). Conclusion Strong TLR1 expression suggested better prognosis in PDAC patients, whereas negative expression of TLR1, TLR3, TLR7, or TLR9 was a sign of poor prognosis. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject CELL-PROLIFERATION
dc.subject EXPRESSION
dc.subject CHEMORESISTANCE
dc.subject PROGRESSION
dc.subject INVASION
dc.subject TLR9
dc.subject 3111 Biomedicine
dc.subject 3122 Cancers
dc.title Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer en
dc.type Article
dc.contributor.organization Department of Surgery
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization CAN-PRO - Translational Cancer Medicine Program
dc.contributor.organization Research Programs Unit
dc.contributor.organization II kirurgian klinikka
dc.contributor.organization University Management
dc.contributor.organization Clinicum
dc.contributor.organization Medicum
dc.contributor.organization Department of Pathology
dc.contributor.organization HUS Helsinki and Uusimaa Hospital District
dc.contributor.organization HUSLAB
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1371/journal.pone.0219245
dc.relation.issn 1932-6203
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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