Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles

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Eymann , J , Salomies , L , Macrì , S & Di-Poï , N 2019 , ' Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles ' , Journal of Comparative Neurology , vol. 527 , no. 14 , pp. 2356-2370 . https://doi.org/10.1002/cne.24677

Title: Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles
Author: Eymann, Julia; Salomies, Lotta; Macrì, Simone; Di-Poï, Nicolas
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Vertebrate Evolution, Development and Regeneration Group
University of Helsinki, Vertebrate Evolution, Development and Regeneration Group
University of Helsinki, Institute of Biotechnology
Date: 2019-10-01
Number of pages: 15
Belongs to series: Journal of Comparative Neurology
ISSN: 0021-9967
URI: http://hdl.handle.net/10138/305387
Abstract: Abstract The retina is a complex, multilayered tissue responsible for the perception of visual stimuli from the environment. Contrary to mammals, the capacity for postnatal eye growth in fish and amphibians, and to a lower extent in birds, is coordinated with a progenitor population residing in the ciliary marginal zone (CMZ) at the retinal peripheral margin. However, little is known about embryonic retinogenesis and postnatal retinal growth in squamates (lizards, snakes), despite their exceptional array of ecologies and ocular morphologies. Here we address this gap by performing the first large-scale study assessing both ontogenetic and adult changes in the stem/progenitor activity of the squamate peripheral retina. Our study reveals for the first time that squamates exhibit a source of proliferating progenitors persisting post embryogenesis in a newly identified retinociliary junction anteriorly adjacent to the retina. This region is strikingly similar to the vertebrate CMZ by its peripheral location and pseudostratified nature, and shares a common pattern of slow-cycling cells, spatial differentiation gradient, and response to postnatal ocular growth. Additionally, its proliferative activity varies considerably among squamate species, in correlation with embryonic and postnatal differences in eye size and growth. Together our data indicate that squamates possess a proliferative peripheral retina that acts as a source of progenitors to compensate, at least in part, for postnatal ocular growth. Our findings also highlight the remarkable variation in activity and location of vertebrate retinal progenitors, indicating that the currently accepted scenario of reduced CMZ activity over the course of evolution is too simplistic. This article is protected by copyright. All rights reserved.
Subject: 1184 Genetics, developmental biology, physiology
squamates
peripheral retina
progenitors
ocular growth
evolution
development
RRID: SCR_007353
RRID: SCR_016299
RRID: AB_2734716
RRID: AB_305426
RRID: AB_305702
RRID: AB_561007
RRID: AB_1795608
RRID: AB_221448
RRID: AB_314691
RRID: AB_2341193
RRID: AB_2239761
RRID: AB_143165
RRID: AB_143157
RRID: SCR_014199
NERVE REGENERATION
PROGENITORS
VISUAL-SYSTEM
EYE SIZE
STEM-CELLS
LIZARD GALLOTIA-GALLOTI
PARS-PLANA
CILIARY MARGINAL ZONE
NEUROGENESIS
NEURAL REGENERATION
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