Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease

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Konki , M , Malonzo , M , Karlsson , I K , Lindgren , N , Ghimire , B , Smolander , J , Scheinin , N M , Ollikainen , M , Laiho , A , Elo , L L , Lonnberg , T , Roytta , M , Pedersen , N L , Kaprio , J , Lahdesmaki , H , Rinne , J O & Lund , R J 2019 , ' Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease ' , Clinical epigenetics , vol. 11 , no. 1 , 130 . https://doi.org/10.1186/s13148-019-0729-7

Title: Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease
Author: Konki, Mikko; Malonzo, Maia; Karlsson, Ida K.; Lindgren, Noora; Ghimire, Bishwa; Smolander, Johannes; Scheinin, Noora M.; Ollikainen, Miina; Laiho, Asta; Elo, Laura L.; Lonnberg, Tapio; Roytta, Matias; Pedersen, Nancy L.; Kaprio, Jaakko; Lahdesmaki, Harri; Rinne, Juha O.; Lund, Riikka J.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-09-02
Language: eng
Number of pages: 12
Belongs to series: Clinical epigenetics
ISSN: 1868-7075
URI: http://hdl.handle.net/10138/305594
Abstract: Background Alzheimer's disease results from a neurodegenerative process that starts well before the diagnosis can be made. New prognostic or diagnostic markers enabling early intervention into the disease process would be highly valuable. Environmental and lifestyle factors largely modulate the disease risk and may influence the pathogenesis through epigenetic mechanisms, such as DNA methylation. As environmental and lifestyle factors may affect multiple tissues of the body, we hypothesized that the disease-associated DNA methylation signatures are detectable in the peripheral blood of discordant twin pairs. Results Comparison of 23 disease discordant Finnish twin pairs with reduced representation bisulfite sequencing revealed peripheral blood DNA methylation differences in 11 genomic regions with at least 15.0% median methylation difference and FDR adjusted p value
Subject: Alzheimer's disease
DNA methylome
Hippocampus
Peripheral blood
Twin pair
CEREBRAL GLUCOSE-METABOLISM
DEMENTIA
SUSCEPTIBILITY
REGISTRY
HISTORY
ADAR3
GENE
ANK1
PET
3122 Cancers
1184 Genetics, developmental biology, physiology
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