Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias

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Ramo , J T , Ripatti , P , Tabassum , R , Soderlund , S , Matikainen , N , Gerl , M J , Klose , C , Surma , M A , Stitziel , N O , Havulinna , A S , Pirinen , M , Salomaa , V , Freimer , N B , Jauhiainen , M , Palotie , A , Taskinen , M-R , Simons , K & Ripatti , S 2019 , ' Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias ' , Journal of the American Heart Association , vol. 8 , no. 13 , 012415 . https://doi.org/10.1161/JAHA.119.012415

Titel: Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias
Författare: Ramo, Joel T.; Ripatti, Pietari; Tabassum, Rubina; Soderlund, Sanni; Matikainen, Niina; Gerl, Mathias J.; Klose, Christian; Surma, Michal A.; Stitziel, Nathan O.; Havulinna, Aki S.; Pirinen, Matti; Salomaa, Veikko; Freimer, Nelson B.; Jauhiainen, Matti; Palotie, Aarno; Taskinen, Marja-Riitta; Simons, Kai; Ripatti, Samuli
Upphovmannens organisation: Institute for Molecular Medicine Finland
Samuli Olli Ripatti / Principal Investigator
Research Programs Unit
HUS Abdominal Center
Centre of Excellence in Complex Disease Genetics
Department of Mathematics and Statistics
Biostatistics Helsinki
Department of Public Health
Aarno Palotie / Principal Investigator
Complex Disease Genetics
Genomics of Neurological and Neuropsychiatric Disorders
Statistical and population genetics
Datum: 2019-07-02
Språk: eng
Sidantal: 38
Tillhör serie: Journal of the American Heart Association
ISSN: 2047-9980
DOI: https://doi.org/10.1161/JAHA.119.012415
Permanenta länken (URI): http://hdl.handle.net/10138/305600
Abstrakt: Background-We asked whether, after excluding familial hypercholesterolemia, individuals with high low-density lipoprotein cholesterol (LDL-C) or triacylglyceride levels and a family history of the same hyperlipidemia have greater coronary artery disease risk or different lipidomic profiles compared with population-based hyperlipidemias. Methods and Results-We determined incident coronary artery disease risk for 755 members of 66 hyperlipidemic families (>2 first-degree relatives with similar hyperlipidemia) and 19 644 Finnish FINRISK population study participants. We quantified 151 circulating lipid species from 550 members of 73 hyperlipidemic families and 897 FINRISK participants using mass spectrometric shotgun lipidomics. Familial hypercholesterolemia was excluded using functional LDL receptor testing and genotyping. Hyperlipidemias (LDL-C or triacylglycerides >90th population percentile) associated with increased coronary artery disease risk in meta-analysis of the hyperlipidemic families and the population cohort (high LDL-C: hazard ratio, 1.74 [95% CI, 1.48-2.04]; high triacylglycerides: hazard ratio, 1.38 [95% CI 1.09-1.74]). Risk estimates were similar in the family and population cohorts also after adjusting for lipid-lowering medication. In lipidomic profiling, high LDL-C associated with 108 lipid species, and high triacylglycerides associated with 131 lipid species in either cohort (at 5% false discovery rate; P-value range 0.038-2.3x 10(-56)). Lipidomic profiles were highly similar for hyperlipidemic individuals in the families and the population (LDL-C: r=0.80; triacylglycerides: r=0.96; no lipid species deviated between the cohorts). Conclusions-Hyperlipidemias with family history conferred similar coronary artery disease risk as population-based hyperlipidemias. We identified distinct lipidomic profiles associated with high LDL-C and triacylglycerides. Lipidomic profiles were similar between hyperlipidemias with family history and population-ascertained hyperlipidemias, providing evidence of similar and overlapping underlying mechanisms.
Subject: coronary artery disease
family study
high-risk populations
hypercholesterolemia
hypertriglyceridemia
lipids and lipoproteins
HOSPITAL DISCHARGE REGISTER
CARDIOVASCULAR-DISEASE
HIGH-THROUGHPUT
HYPERCHOLESTEROLEMIA
HYPERTRIGLYCERIDEMIA
DEATH
SOCIETY
3141 Health care science
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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