Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias

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dc.contributor.author Ramo, Joel T.
dc.contributor.author Ripatti, Pietari
dc.contributor.author Tabassum, Rubina
dc.contributor.author Soderlund, Sanni
dc.contributor.author Matikainen, Niina
dc.contributor.author Gerl, Mathias J.
dc.contributor.author Klose, Christian
dc.contributor.author Surma, Michal A.
dc.contributor.author Stitziel, Nathan O.
dc.contributor.author Havulinna, Aki S.
dc.contributor.author Pirinen, Matti
dc.contributor.author Salomaa, Veikko
dc.contributor.author Freimer, Nelson B.
dc.contributor.author Jauhiainen, Matti
dc.contributor.author Palotie, Aarno
dc.contributor.author Taskinen, Marja-Riitta
dc.contributor.author Simons, Kai
dc.contributor.author Ripatti, Samuli
dc.date.accessioned 2019-09-24T15:58:03Z
dc.date.available 2019-09-24T15:58:03Z
dc.date.issued 2019-07-02
dc.identifier.citation Ramo , J T , Ripatti , P , Tabassum , R , Soderlund , S , Matikainen , N , Gerl , M J , Klose , C , Surma , M A , Stitziel , N O , Havulinna , A S , Pirinen , M , Salomaa , V , Freimer , N B , Jauhiainen , M , Palotie , A , Taskinen , M-R , Simons , K & Ripatti , S 2019 , ' Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias ' , Journal of the American Heart Association , vol. 8 , no. 13 , 012415 . https://doi.org/10.1161/JAHA.119.012415
dc.identifier.other PURE: 126941782
dc.identifier.other PURE UUID: 84f66675-9ba7-47b7-8c16-199a9ac36141
dc.identifier.other WOS: 000484578700022
dc.identifier.other ORCID: /0000-0002-1664-1350/work/62278995
dc.identifier.other ORCID: /0000-0002-6429-5149/work/62280516
dc.identifier.other ORCID: /0000-0002-6229-3588/work/90756892
dc.identifier.other ORCID: /0000-0003-0041-1240/work/94378147
dc.identifier.other ORCID: /0000-0002-2527-5874/work/97266367
dc.identifier.uri http://hdl.handle.net/10138/305600
dc.description.abstract Background-We asked whether, after excluding familial hypercholesterolemia, individuals with high low-density lipoprotein cholesterol (LDL-C) or triacylglyceride levels and a family history of the same hyperlipidemia have greater coronary artery disease risk or different lipidomic profiles compared with population-based hyperlipidemias. Methods and Results-We determined incident coronary artery disease risk for 755 members of 66 hyperlipidemic families (>2 first-degree relatives with similar hyperlipidemia) and 19 644 Finnish FINRISK population study participants. We quantified 151 circulating lipid species from 550 members of 73 hyperlipidemic families and 897 FINRISK participants using mass spectrometric shotgun lipidomics. Familial hypercholesterolemia was excluded using functional LDL receptor testing and genotyping. Hyperlipidemias (LDL-C or triacylglycerides >90th population percentile) associated with increased coronary artery disease risk in meta-analysis of the hyperlipidemic families and the population cohort (high LDL-C: hazard ratio, 1.74 [95% CI, 1.48-2.04]; high triacylglycerides: hazard ratio, 1.38 [95% CI 1.09-1.74]). Risk estimates were similar in the family and population cohorts also after adjusting for lipid-lowering medication. In lipidomic profiling, high LDL-C associated with 108 lipid species, and high triacylglycerides associated with 131 lipid species in either cohort (at 5% false discovery rate; P-value range 0.038-2.3x 10(-56)). Lipidomic profiles were highly similar for hyperlipidemic individuals in the families and the population (LDL-C: r=0.80; triacylglycerides: r=0.96; no lipid species deviated between the cohorts). Conclusions-Hyperlipidemias with family history conferred similar coronary artery disease risk as population-based hyperlipidemias. We identified distinct lipidomic profiles associated with high LDL-C and triacylglycerides. Lipidomic profiles were similar between hyperlipidemias with family history and population-ascertained hyperlipidemias, providing evidence of similar and overlapping underlying mechanisms. en
dc.format.extent 38
dc.language.iso eng
dc.relation.ispartof Journal of the American Heart Association
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject coronary artery disease
dc.subject family study
dc.subject high-risk populations
dc.subject hypercholesterolemia
dc.subject hypertriglyceridemia
dc.subject lipids and lipoproteins
dc.subject HOSPITAL DISCHARGE REGISTER
dc.subject CARDIOVASCULAR-DISEASE
dc.subject HIGH-THROUGHPUT
dc.subject HYPERCHOLESTEROLEMIA
dc.subject HYPERTRIGLYCERIDEMIA
dc.subject DEATH
dc.subject SOCIETY
dc.subject 3141 Health care science
dc.title Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Samuli Olli Ripatti / Principal Investigator
dc.contributor.organization Research Programs Unit
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Centre of Excellence in Complex Disease Genetics
dc.contributor.organization Department of Mathematics and Statistics
dc.contributor.organization Biostatistics Helsinki
dc.contributor.organization Department of Public Health
dc.contributor.organization Aarno Palotie / Principal Investigator
dc.contributor.organization Complex Disease Genetics
dc.contributor.organization Genomics of Neurological and Neuropsychiatric Disorders
dc.contributor.organization Statistical and population genetics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1161/JAHA.119.012415
dc.relation.issn 2047-9980
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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