Anti-inflammatory medication following cataract surgery : a randomized trial between preservative-free dexamethasone, diclofenac and their combination

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Ylinen , P , Holmstrom , E , Laine , I , Lindholm , J-M & Tuuminen , R 2018 , ' Anti-inflammatory medication following cataract surgery : a randomized trial between preservative-free dexamethasone, diclofenac and their combination ' , Acta Ophthalmologica , vol. 96 , no. 5 , pp. 486-493 . https://doi.org/10.1111/aos.13670

Title: Anti-inflammatory medication following cataract surgery : a randomized trial between preservative-free dexamethasone, diclofenac and their combination
Author: Ylinen, Petteri; Holmstrom, Emil; Laine, Ilkka; Lindholm, Juha-Matti; Tuuminen, Raimo
Contributor: University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Transplantation Laboratory
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
Date: 2018-08
Language: eng
Number of pages: 8
Belongs to series: Acta Ophthalmologica
ISSN: 1755-375X
URI: http://hdl.handle.net/10138/305625
Abstract: PurposeTo examine the anti-inflammatory efficacy and tolerance between preservative-free dexamethasone (DEX) and diclofenac (DICL) eye drops, and their combination following cataract surgery. MethodsA randomized, double-blind, prospective single-centre study with 189 eyes of 180 patients undergoing routine cataract surgery. Laser flare meter measurement and spectral-domain optical coherence tomography imaging were conducted before surgery and at the 28-day postoperative visit. Clinical characteristics, surgical parameters and assessment of postoperative symptoms were recorded. ResultsPreoperative flare was 9.00.6pu/ms and central retinal thickness (CRT) 269.6 +/- 1.9m (mean +/- SEM). On day 28, flare was 22.1 +/- 2.9 pu/ms for DEX, 17.4 +/- 2.5pu/ms for DICL and 13.0 +/- 1.6pu/ms (p ConclusionDiclofenac (DICL), as well as the combination of DEX and DICL, were superior to DEX monotherapy in minimizing CRT change and the incidence of PCME. Combination medication showed no added value compared to DICL monotherapy in uneventful cataract surgery.
Subject: aqueous flare
cataract
central retinal thickness
dexamethasone
diclofenac
nonsteroidal anti-inflammatory drug
phacoemulsification
pseudophakic cystoid macular oedema
CYSTOID MACULAR EDEMA
OPTICAL COHERENCE TOMOGRAPHY
FUNDUS FLUORESCEIN ANGIOGRAPHY
DIABETIC-RETINOPATHY
NEPAFENAC 0.1-PERCENT
RISK-FACTORS
EYE DROPS
PHACOEMULSIFICATION
PREVENTION
DRUGS
3125 Otorhinolaryngology, ophthalmology
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