Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study

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Rasouli , B , Ahlqvist , E , Alfredsson , L , Andersson , T , Carlsson , P-O , Groop , L , Löfvenborg , J E , Martinell , M , Rosengren , A , Tuomi , T , Wolk , A & Carlsson , S 2018 , ' Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study ' , Diabetes & metabolism , vol. 44 , no. 4 , pp. 354-360 . https://doi.org/10.1016/j.diabet.2018.05.002

Title: Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study
Author: Rasouli, B.; Ahlqvist, E.; Alfredsson, L.; Andersson, T.; Carlsson, P.-O.; Groop, L.; Löfvenborg, J.E.; Martinell, M.; Rosengren, A.; Tuomi, T.; Wolk, A.; Carlsson, S.
Contributor: University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Centre of Excellence in Complex Disease Genetics
Date: 2018-09
Language: eng
Number of pages: 7
Belongs to series: Diabetes & metabolism
ISSN: 1262-3636
URI: http://hdl.handle.net/10138/305740
Abstract: Aim. - Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods. - This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction. Results. - Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02-1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93-1.17). Subjects with both heavy coffee consumption (>= 4 cups day) and high-risk HLA genotypes had an OR of 5.74 (95% Cl: 3.34-9.88) with an estimated AP of 0.36 (95% CI: 0.01-0.71; P = 0.04370). Conclusion. - Our findings suggest that coffee consumption interacts with HLA to promote LADA. (C) 2018 Elsevier Masson SAS. All rights reserved.
Subject: 3121 General medicine, internal medicine and other clinical medicine
Autoimmune diabetes
Coffee consumption
Gene-environmental interaction
Latent autoimmune diabetes in adults
LADA
Type 2 diabetes
RHEUMATOID-ARTHRITIS
DECAFFEINATED COFFEE
TEA CONSUMPTION
TYPE-2
FREQUENCY
MELLITUS
DISEASE
ACID
AUTOANTIBODIES
ASSOCIATIONS
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