Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study

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Rasouli , B , Ahlqvist , E , Alfredsson , L , Andersson , T , Carlsson , P-O , Groop , L , Löfvenborg , J E , Martinell , M , Rosengren , A , Tuomi , T , Wolk , A & Carlsson , S 2018 , ' Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study ' , Diabetes & metabolism , vol. 44 , no. 4 , pp. 354-360 . https://doi.org/10.1016/j.diabet.2018.05.002

Title: Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study
Author: Rasouli, B.; Ahlqvist, E.; Alfredsson, L.; Andersson, T.; Carlsson, P.-O.; Groop, L.; Löfvenborg, J.E.; Martinell, M.; Rosengren, A.; Tuomi, T.; Wolk, A.; Carlsson, S.
Contributor organization: Centre of Excellence in Complex Disease Genetics
Institute for Molecular Medicine Finland
University of Helsinki
Diabetes and Obesity Research Program
Research Programs Unit
Department of Medicine
Clinicum
Endokrinologian yksikkö
HUS Abdominal Center
Date: 2018-09
Language: eng
Number of pages: 7
Belongs to series: Diabetes & metabolism
ISSN: 1262-3636
DOI: https://doi.org/10.1016/j.diabet.2018.05.002
URI: http://hdl.handle.net/10138/305740
Abstract: Aim. - Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods. - This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction. Results. - Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02-1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93-1.17). Subjects with both heavy coffee consumption (>= 4 cups day) and high-risk HLA genotypes had an OR of 5.74 (95% Cl: 3.34-9.88) with an estimated AP of 0.36 (95% CI: 0.01-0.71; P = 0.04370). Conclusion. - Our findings suggest that coffee consumption interacts with HLA to promote LADA. (C) 2018 Elsevier Masson SAS. All rights reserved.
Description: Export Date: 31 October 2018
Subject: 3121 General medicine, internal medicine and other clinical medicine
Autoimmune diabetes
Coffee consumption
Gene-environmental interaction
Latent autoimmune diabetes in adults
LADA
Type 2 diabetes
RHEUMATOID-ARTHRITIS
DECAFFEINATED COFFEE
TEA CONSUMPTION
TYPE-2
FREQUENCY
MELLITUS
DISEASE
ACID
AUTOANTIBODIES
ASSOCIATIONS
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: draft


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