Rasouli , B , Ahlqvist , E , Alfredsson , L , Andersson , T , Carlsson , P-O , Groop , L , Löfvenborg , J E , Martinell , M , Rosengren , A , Tuomi , T , Wolk , A & Carlsson , S 2018 , ' Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study ' , Diabetes & metabolism , vol. 44 , no. 4 , pp. 354-360 . https://doi.org/10.1016/j.diabet.2018.05.002
Title: | Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study |
Author: | Rasouli, B.; Ahlqvist, E.; Alfredsson, L.; Andersson, T.; Carlsson, P.-O.; Groop, L.; Löfvenborg, J.E.; Martinell, M.; Rosengren, A.; Tuomi, T.; Wolk, A.; Carlsson, S. |
Contributor organization: | Centre of Excellence in Complex Disease Genetics Institute for Molecular Medicine Finland University of Helsinki Diabetes and Obesity Research Program Research Programs Unit Department of Medicine Clinicum Endokrinologian yksikkö HUS Abdominal Center |
Date: | 2018-09 |
Language: | eng |
Number of pages: | 7 |
Belongs to series: | Diabetes & metabolism |
ISSN: | 1262-3636 |
DOI: | https://doi.org/10.1016/j.diabet.2018.05.002 |
URI: | http://hdl.handle.net/10138/305740 |
Abstract: | Aim. - Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods. - This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction. Results. - Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02-1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93-1.17). Subjects with both heavy coffee consumption (>= 4 cups day) and high-risk HLA genotypes had an OR of 5.74 (95% Cl: 3.34-9.88) with an estimated AP of 0.36 (95% CI: 0.01-0.71; P = 0.04370). Conclusion. - Our findings suggest that coffee consumption interacts with HLA to promote LADA. (C) 2018 Elsevier Masson SAS. All rights reserved. |
Description: | Export Date: 31 October 2018 |
Subject: |
3121 General medicine, internal medicine and other clinical medicine
Autoimmune diabetes Coffee consumption Gene-environmental interaction Latent autoimmune diabetes in adults LADA Type 2 diabetes RHEUMATOID-ARTHRITIS DECAFFEINATED COFFEE TEA CONSUMPTION TYPE-2 FREQUENCY MELLITUS DISEASE ACID AUTOANTIBODIES ASSOCIATIONS |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | draft |
Total number of downloads: Loading...
Files | Size | Format | View |
---|---|---|---|
Coffee_consumpt ... sed_case_control_study.pdf | 460.6Kb |
View/ |