Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis : a longitudinal study of the Nordic JIA cohort

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Nordic Study Grp Pediat Rheumatolo , Glerup , M , Thiel , S , Rypdal , V , Peltoniemi , S , Aalto , K & Herlin , T 2019 , ' Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis : a longitudinal study of the Nordic JIA cohort ' , Pediatric Rheumatology Online Journal , vol. 17 , no. 1 , 63 . https://doi.org/10.1186/s12969-019-0367-9

Title: Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis : a longitudinal study of the Nordic JIA cohort
Author: Nordic Study Grp Pediat Rheumatolo; Glerup, Mia; Thiel, Steffen; Rypdal, Veronika; Peltoniemi, Suvi; Aalto, Kristiina; Herlin, Troels
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
Date: 2019-09-09
Language: eng
Number of pages: 9
Belongs to series: Pediatric Rheumatology Online Journal
ISSN: 1546-0096
URI: http://hdl.handle.net/10138/305747
Abstract: Background To determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants from a population-based Nordic juvenile idiopathic arthritis (JIA) cohort. Additionally, to assess the predictive value of lectin pathway proteins with respect to remission status. Methods A population-based cohort study of consecutive cases of JIA with a disease onset from 1997 to 2000 from defined geographical areas of Finland, Sweden, Norway and Denmark with 17 years of follow-up was performed. Clinical characteristics were registered and H-ficolin, M-ficolin, MASP-1, MASP-3, MBL and CL-K1 levels in serum were analyzed. Results In total, 293 patients with JIA were included (mean age 23.7 +/- 4.4 years; mean follow-up 17.2 +/- 1.7 years). Concentrations of the lectin protein levels in serum were higher at baseline compared to the levels 17 years after disease onset (p
Subject: JIA
Lectin pathway proteins
Disease activity
MANNOSE-BINDING LECTIN
PATTERN-RECOGNITION MOLECULES
RHEUMATOID-ARTHRITIS
IMMUNE-COMPLEXES
ACTIVATION
POLYMORPHISMS
POPULATION
CATEGORIES
REMISSION
FICOLIN
3123 Gynaecology and paediatrics
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