Clostridium difficile infection in patients with inflammatory bowel disease : a case control study

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Vitikainen , K , Haapamaki , J , Farkkila , M , Anttila , V-J & Arkkila , P 2018 , ' Clostridium difficile infection in patients with inflammatory bowel disease : a case control study ' , Scandinavian Journal of Gastroenterology , vol. 53 , no. 8 , pp. 947-951 . https://doi.org/10.1080/00365521.2018.1492012

Title: Clostridium difficile infection in patients with inflammatory bowel disease : a case control study
Author: Vitikainen, Krista; Haapamaki, Johanna; Farkkila, Martti; Anttila, Veli-Jukka; Arkkila, Perttu
Contributor: University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Doctoral Programme in Clinical Research
University of Helsinki, Doctoral Programme in Clinical Research
Date: 2018
Number of pages: 5
Belongs to series: Scandinavian Journal of Gastroenterology
ISSN: 0036-5521
URI: http://hdl.handle.net/10138/305915
Abstract: Objective: Characterization of predisposing factors for Clostridium difficile infection recurrence (rCDI) and outcome in inflammatory bowel disease (IBD) patients.Methods: Clinical characteristics of 167 inflammatory bowel disease patients with Clostridium difficile infection (IBD-CDI cohort) treated in Helsinki University Central Hospital were gathered. Medical history of the last three months preceding a toxin positive CDI test was recorded. Parameters, including ribotype of C. difficile, mortality and recurrence were compared with age and gender-matched C. difficile patients (CDI cohort).Results: No difference was found in rCDI between IBD-CDI and CDI cohorts. As compared with IBD subtypes, rCDI was least common among patients with Crohn's disease. The use of immunosuppressant therapy was higher in IBD patients with two or more CDI episodes. C. difficile ribotype 027 increased the rates for rCDI in IBD patients but not in non-IBD-CDI patients. The prevalence of 027 ribotype and mortality rates did not differ significantly among the cohorts. None of the IBD patients underwent colectomy upon CDI.Conclusion: IBD patients are not more susceptible for rCDI than non-IBD patients. Predisposing factors for rCDI among IBD patients are associated with immunosuppressant treatments, colon affecting IBD and CDI caused by ribotype 027. CDI does not worsen the prognosis of IBD patients.
Subject: Inflammatory bowel disease
ulcerative colitis
Crohn's disease
Clostridium difficile infection
recurrence of C
difficile infection
HOSPITALIZED-PATIENTS
INCREASING INCIDENCE
RISK-FACTORS
DIARRHEA
IMPACT
EPIDEMIOLOGY
METAANALYSIS
PREVALENCE
MANAGEMENT
MORTALITY
3121 Internal medicine
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