Genetic and environmental factors affecting birth size variation : a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

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Yokoyama , Y , Jelenkovic , A , Hur , Y-M , Sund , R , Fagnani , C , Stazi , M A , Brescianini , S , Ji , F , Ning , F , Pang , Z , Knafo-Noam , A , Mankuta , D , Abramson , L , Rebato , E , Hopper , J L , Cutler , T L , Saudino , K J , Nelson , T L , Whitfield , K E , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Loos , R J F , Llewellyn , C H , Fisher , A , Bjerregaard-Andersen , M , Beck-Nielsen , H , Sodemann , M , Krueger , R F , McGue , M , Pahlen , S , Bartels , M , van Beijsterveldt , C E M , Willemsen , G , Harris , J R , Brandt , I , Nilsen , T S , Craig , J M , Saffery , R , Dubois , L , Boivin , M , Brendgen , M , Dionne , G , Vitaro , F , Haworth , C M A , Plomin , R , Bayasgalan , G , Narandalai , D , Rasmussen , F , Tynelius , P , Tarnoki , A D , Tarnoki , D L , Ooki , S , Rose , R J , Pietilainen , K H , Sorensen , T I A , Boomsma , D I , Kaprio , J & Silventoinen , K 2018 , ' Genetic and environmental factors affecting birth size variation : a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts ' , International Journal of Epidemiology , vol. 47 , no. 4 , pp. 1195-1206 .

Title: Genetic and environmental factors affecting birth size variation : a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts
Author: Yokoyama, Yoshie; Jelenkovic, Aline; Hur, Yoon-Mi; Sund, Reijo; Fagnani, Corrado; Stazi, Maria A.; Brescianini, Sonia; Ji, Fuling; Ning, Feng; Pang, Zengchang; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Rebato, Esther; Hopper, John L.; Cutler, Tessa L.; Saudino, Kimberly J.; Nelson, Tracy L.; Whitfield, Keith E.; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Llewellyn, Clare H.; Fisher, Abigail; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Bartels, Meike; van Beijsterveldt, Catharina E. M.; Willemsen, Gonneke; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas S.; Craig, Jeffrey M.; Saffery, Richard; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Haworth, Claire M. A.; Plomin, Robert; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Rasmussen, Finn; Tynelius, Per; Tarnoki, Adam D.; Tarnoki, David L.; Ooki, Syuichi; Rose, Richard J.; Pietilainen, Kirsi H.; Sorensen, Thorkild I. A.; Boomsma, Dorret I.; Kaprio, Jaakko; Silventoinen, Karri
Contributor organization: Population Research Unit (PRU)
Academic Disciplines of the Faculty of Social Sciences
Department of Social Research (2010-2017)
Research Units of the Faculty of Social Sciences
Doctoral Programme in Population Health
Doctoral Programme in Clinical Research
Research Programs Unit
Diabetes and Obesity Research Program
Kirsi Hannele Pietiläinen / Principal Investigator
Endokrinologian yksikkö
Department of Medicine
Institute for Molecular Medicine Finland
Jaakko Kaprio / Principal Investigator
Department of Public Health
Center for Population, Health and Society
HUS Abdominal Center
Genetic Epidemiology
Date: 2018-08
Language: eng
Number of pages: 12
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
Abstract: Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled. Genetic and environmental variations of birth size were estimated using genetic structural equation modelling. Results: The variance of birthweight and length was predominantly explained by shared environmental factors, whereas the variance of PI was explained both by shared and unique environmental factors. Genetic variance contributing to birth size was small. Adjusting for gestational age decreased the proportions of shared environmental variance and increased the propositions of unique environmental variance. Genetic variance was similar in the geographical-cultural regions, but shared environmental variance was smaller in East Asia than in Europe and North America and Australia. The total variance and shared environmental variance of birth length and PI were greater from the birth cohort 1990-99 onwards compared with the birth cohorts from 1970-79 to 1980-89. Conclusions: The contribution of genetic factors to birth size is smaller than that of shared environmental factors, which is partly explained by gestational age. Shared environmental variances of birth length and PI were greater in the latest birth cohorts and differed also across geographical-cultural regions. Shared environmental factors are important when explaining differences in the variation of birth size globally and over time.
Subject: Birthweight
birth length
ponderal index
pooled studies
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion

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