Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

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dc.contributor.author Paaver, Urve
dc.contributor.author Heinämäki, Jyrki
dc.contributor.author Kassamakov, Ivan
dc.contributor.author Ylitalo, Tuomo
dc.contributor.author Hæggström, Edward
dc.contributor.author Laidmäe, Ivo
dc.contributor.author Kogermann, Karin
dc.date.accessioned 2019-10-11T15:51:14Z
dc.date.available 2019-10-11T15:51:14Z
dc.date.issued 2019-09-24
dc.identifier.citation Paaver, U.; Heinämäki, J.; Kassamakov, I.; Ylitalo, T.; Hæggström, E.; Laidmäe, I.; Kogermann, K. Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam. Pharmaceutics 2019, 11, 491.
dc.identifier.uri http://hdl.handle.net/10138/305959
dc.description.abstract We investigated and monitored in situ the wetting and dissolution properties of polymeric nanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used as a low-dose and poorly-soluble model drug, and hydroxypropyl methylcellulose (HPMC) and polydextrose (PD) were used as carrier polymers for electrospinning (ES). The initial-stage dissolution of the nanofibers was monitored in situ with three-dimensional white light microscopic interferometry (SWLI) and high-resolution optical microscopy. The physical solid-state characterization of nanofibers was performed with Raman spectroscopy, X-ray powder diffraction (XRPD), and scanning electron microscopy (SEM). We showed that PRX recrystallizes in a microcrystalline form immediately after wetting of nanofibers, which could lead to enhanced dissolution of drug. Initiation of crystal formation was detected by SWLI, indicating: (1) that PRX was partially released from the nanofibers, and (2) that the solid-state form of PRX changed from amorphous to crystalline. The amount, shape, and size of the PRX crystals depended on the carrier polymer used in the nanofibers and dissolution media (pH). In conclusion, the present nanofibers loaded with PRX exhibit a quasi-dynamic dissolution via recrystallization. SWLI enables a rapid, non-contacting, and non-destructive method for in situ monitoring the early-stage dissolution of nanofibers and regional mapping of crystalline changes (re-crystallization) during wetting. Such analysis is crucial because the wetting and dissolution of nanofibers can greatly influence the performance of nanofibrous drug delivery systems in pharmaceutical and biomedical applications.
dc.language.iso eng
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam en
dc.date.updated 2019-10-11T15:51:14Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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